目的 探讨超声引导下个体化经直肠前列腺穿刺活检术(TUGPB)在前列腺癌(PCa)诊断中的应用价值。方法 对121例 有前列腺穿刺指征的患者采用个体化穿刺方案，在经直肠超声引导下行前列腺穿刺活检术，根据病情采取6-13点个 性化穿刺方案。结果 本组121例患者前列腺活检共检出前列腺癌49例，阳性率为40.5%，其中T1-T2期3例、T3-T4期 46例，Gleason评分2-4分2例，5-7分8例，8-10分39例。前列腺增生(benign prostatic hyperplasia，BPH)48例， 前列腺增生伴慢性炎症5例，前列腺上皮内瘤变(prostatic intraepithelial neoplasm，PIN)19例。无前列腺脓 肿、会阴部急性蜂窝织炎、大出血等严重并发症。结论 经直肠超声引导前列腺穿刺活术在前列腺癌诊断中是一项 安全、可靠、有效、易于掌握的方法。在临床工作中采用个体化的穿刺方案可减少患者痛苦，降低并发症的发生。

Objective To investigate the value of individual transrectal ultrasound-guided prostate biopsy in the diagnosis of prostate carcinoma. Methods 121 cases of patients accepted individual transrectal ultrasound-guided prostate biopsy, puncture 6-13specimens according to patient's condition. Results 49 cases of 121 patients detected prostate carcinoma (with positive rate 40.5%), tumor stage range T1-T2 (3cases), T3-T4 (46cases), gleason scores range 2-4 (2cases), 5-7 (39cases), 8-10 (39cases), prostatic hyperplasia 48 cases, prostatic hyperplasia wth cronic postatitis 5cases, prostatic intraepithelial neoplasm 19 cases, with no serious complications such as prostatic abscess, perineal acute cellulitis and massive hemorrhage. Conclusions Individual transrectal ultrasound-guided prostate biopsy is a safe, reliable, effective and easy method in prostate carcinoma diagnosis, which can reduce the suffering of patients and the incidence of complications.