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产前胎盘植入的MR 表现与诊断价值*

作者:杨 昆1 李雪梅2 黄含音3 陈园元4 姜 颖1 崔梦秋1 涂 蓉5

所属单位:1.海南医学院 (海南 海口 570100) 2.云南省镇雄县人民医院超声科 (云南 昆明 657200) 3.海南医学院第二附属医院超声科 (海南 海口 570100) 4.海南海口市人民医院超声科 (海南 海口 570100) 5.海南医学院第一附属医院放射科 (海南 海口 570100)

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摘要

目的 探讨产前胎盘植入MRI表现 及其诊断价值。方法 收集105例临床疑产 前胎盘植入患者相关资料,包括妊娠史 等一般资料、术前MRI和超声所见和诊 断、手术和/或病理结果,以手术和/或病 理结果为参照标准,分析胎盘植入的主要 MRI征象,评估MRI与超声预测胎盘植入的 诊断效能;评价MRI与手术或病理分型诊 断的一致性。结果 105例疑有胎盘植入患 者中,病理证实有胎盘植入的45例,其中 穿透性植入22例、肌层植入13例、胎盘粘 连10例;MR拟诊阳性或可疑阳性74例。 MR评估产前胎盘植入的灵敏度0.98、特异 度0.48、阳性预测值0.55、阴性预测值 0.97;超声产前胎盘植入的灵敏度0.52、 特异度0.86、阳性预测值0.76、阴性预 测值0.73,两者差异有统计学意义,P值 <0.05。在产前胎盘植入的MR各种征象 中,子宫肌层与胎盘结构分界不清的有51 例,真阳性者36例,假阳性者15例,准确 率71%;胎盘与膀胱壁分界不清的有3例, 准确率100%;其他征象都相对少见或价值 有限。结论 MRI对产前胎盘植入诊断灵敏 度较超声好,但特异度低于超声。采用 MRI对胎盘植入进行诊断时,可显示多种 相关征象,其中膀胱壁与胎盘结构分界不 清为诊断胎盘植入的最可靠征象。

Objective To investigate the MR imaging findings of placental implantation and its prenatal diagnostic value. Methods Data of 105 patients with suspicion of placental implantation who had undergone MR and color Doppler ultrasound (US) evaluation in the second and third trimester gestation were collected retrospectively, including MRI findings and color Doppler ultrasonography of the placental implantation, the prenatal diagnosis, surgical evidence, pathological diagnosis, and so on. Taking surgical evidence or histopathology as reference, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI and US for the evaluation of placental implantation were determined. Results Of the 105 patients with suspicion of placenta implantation, 45 cases were consistent with pathology, including 22 cases of penetrating implantation, 13 cases of myometrium placenta implantation, and 10 cases of placenta adhesion; and 74 patients were assumed placenta accrata or suspected placenta accrata based on MRI. The sensitivity, specificity, positive predictive value, and negative predictive value of MRI and US for the evaluation of placenta implantation were 0.98 and 0.52, 0.48 and 0.86, 0.55 and 0.76, and 0.97 and 0.73, respectively(P<0.05). On MRI imaging, 51 patients showed lose of or ambiguous and blurry placental myometrial interface, 36 of them had placenta implantation, 15 of them did not have placenta implantation, and the accuracy was 71%. 3 patients with lose of the placental urinary bladder interface showing on the contrast-enhanced MRI were confirmed placenta implantation, the accuracy was 100%; the other abnormal findings on MRI were relatively rare, and they had limited value for the evaluation of placenta implantation. Conclusion Compared with color Doppler ultrasonography for the evaluation of placenta implantation, MRI has higher sensitivity and lower specificity. The lose of the placental urinary bladder interface on the contrastenhanced MRI is a reliable characteristic for the diagnosis of placenta implantation.

【关键词】产前;胎盘植入;磁共振成 像;超声;诊断

【中图分类号】R714.462;R445.1;R445.2

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.01.035

前言

胎盘植入是由于子宫底蜕膜发育不良,胎盘绒毛侵入或穿透子宫 肌层所致的一种异常的胎盘种植。按植入程度不同,胎盘绒毛达深部 肌层,称植入性胎盘;更深者,胎盘绒毛可达浆膜层,甚至可穿透浆膜 层,达膀胱或直肠,称穿透性胎盘[1]。胎盘植入多发生于子宫切开手 术后的几年内再次受孕时,孕囊种植或附着于切口瘢痕裂隙处,绒 毛透过内膜向肌层内植入,孕囊周围被纤维组织及子宫肌层包裹。 以剖宫产术后的二次妊娠最多见,随着剖宫产手术率的增高(2015年 30.63%)[2]及国家二孩政策的落实,产妇罹患胎盘植入的风险逐年增 高,剖宫产病史的患者的胎盘植入发生率增加至40%~60%[3],已经成 为产科常见病与多发病,是一种妊娠晚期常见的出血性、致死性疾 病,严重威胁产妇的生命。因此,产前胎盘植入诊断的准确性、可靠 性越来越受到妇产科医师的关注。目前临床上对胎盘植入诊断主要采 用超声检查,50%~80%的胎盘植入病例可通过超声进行检查,而磁共 振成像是一种必要补充检查方法[4]。但由于部分孕妇腹壁组织较厚、 肠道积气及骨骼的干扰,后壁胎盘等原因,使得部分产妇超声图像的 分辨能力不佳,影响诊断,导致漏诊或误诊。MRI可以全面、多体位、 多参数评价妊娠子宫,在孕期的应用价值逐渐得到人们的重视[5],但目前国内并没有统一的MR诊断标 准,与超声影像比较,MR的诊断 价值、主要的影像学特征尚缺乏 大数据报道,且目前MR研究多以 产后的胎盘植入为主。本研究试 图通过回顾性分析产前临床疑似 胎盘植入的病例105例,将MRI和 超声结果与临床手术、病理结果 进行对照研究,进一步提高对产 前胎盘植入MR征象的认识,以提 高对其诊断能力。