目的分析核磁共振成像 (Magnetic Resonance Imaging，MRI) 在格林-巴利综合征(Guillain-Barre syndrome，GBS)胫神经、腓总神经损伤 评估中的应用。方法 选取我院60例GBS 患者与同期60名正常志愿者纳入研究， 分为研究组与对照组，均给予MRI检查， 包括MR扩散张量成像(Diffusion Tensor Imaging,DTI)，比较2组胫神经与腓总神 经检查结果[径向扩散系数(RD)、轴向扩 散系数(AD)、各向异性分数(FA)、表观扩 散系数(ADC)]，并采取纤维束示踪成像 (Diffusion Tensor Tractography,DTT) 技术获取影像学图像。结果 研究组 胫神经RD、AD、FA明显小于对照组 (P＜0.05)，且ADC明显大于对照组(P ＜0.05)；研究组腓总神经RD、AD、FA明 显小于对照组(P＜0.05)，ADC显著大于 对照组(P＜0.05)；MRI检查GBS，SPAIR T2WI像显示患者去神经支配骨骼肌可见肌 肉信号增强，并且边界欠清晰；GBS患者 DTT中胫神经、腓总神经影像较清晰或者 稍差，呈现边缘模糊及扭曲变形现象，信 号强度有所减弱，显示神经纤细毛糙，相 较于正常志愿者，其纤维数量有所减少。 结论 MRI检查相关参数能用于GBS胫神经 与腓总神经损伤方面的评估，MR可清晰显 示胫神经与腓总神经相应支配区骨骼肌产 生的去神经变化，具有较高临床应用价 值。

Objective To analyze the application of magnetic resonance imaging (MRI) in the evaluation of tibial and common peroneal nerve injuries in Green-Barre syndrome (GBS). Methods A total of 60 patients with GBS in the hospital and 60 normal volunteers were enrolled in the study. They were included in the study group and the control group, respectively. All of them were examined by MRI, including MR diffusion tensor imaging (DTI). The examination results of tibial and common peroneal nerves [radial diffusion coefficient (RD), axial diffusion coefficient (AD), fractional anisotropy (FA), apparent diffusion coefficient (ADC)] were compared between the two groups. The images were obtained by diffusion tensor tractography (DTT). Results The RD, AD and FA of tibial nerve in the study group were significantly lower than those in the control group (P<0.05), while the ADC was significantly larger than that in the control group (P<0.05). The RD, AD and FA of the common peroneal nerve in the study group were significantly lower than those in the control group (P<0.05), while the ADC was significantly larger than that in the control group (P<0.05). In terms of MRI examination for GBS, SPAIR T2WI images showed muscle signal enhancement of the denervated skeletal muscles and unclear boundaries. The DTT for GBS found that the images of tibial and peroneal nerves were clear or slightly unclear, showing blurred boundaries and distorted phenomenon. The signal intensity was weakened, indicating that the nerve was fine and rough. Compared with normal volunteers, the number of fibers was decreased. Conclusion The related parameters of MRI examination can be used to evaluate the tibial and peroneal nerve injuries in CBS. MR can show the denervated changes in skeletal muscles in the corresponding dominating area of the tibial and peroneal nerves clearly, which is of great clinical value.