目的探讨基于CT直方图定量分 析技术鉴别肺磨玻璃结节良、恶性的临床 应用价值。方法 选择2016年1月到2017 年12月123例肺局灶性磨玻璃密度结节患 者，采用飞利浦64排螺旋CT仪器扫描，基 于CT直方图定量分析技术鉴别肺磨玻璃 结节良恶性的临床应用价值。结果 (1) 在病灶大小方面，良性病变和恶性病变 无统计学差异，P>0.05；在病灶形态方 面，良性病变比恶性病变患者病灶球状、 分叶状、不规则形的占比明显更少，有 统计学意义，P<0.05。(2)在病灶边缘方 面，良性病变比恶性病变毛刺、分叶的患 者少；同样在病灶边界方面，良性病变 比恶性病变边界清晰，差异均具有统计 学意义(P<0.05)。(3)良性病变和恶性病 变的PET/CT-SUVmax值对比无明显差异， P>0.05。(4)和恶性病变对比，良性病变 的平均CT值和最高峰值明显更高，数据差 异明显，P<0.05。结论 多层螺旋CT在诊 断肺部局灶性磨玻璃密度结节中效果显 著，在判定fGGO病灶性质上准确率较高。

Objective To evaluate the clinical value of quantitative analysis of CT histogram in differentiating benign and malignant pulmonary grind glass nodule. Methods A total of 123 cases of pulmonary focal milled glass density nodules from January 2016 to December 2017 were selected to be scanned by PHILPS 64 row spiral CT instrument. The clinical value of CT histogram quantitative analysis was used to identify the benign and malignant pulmonary nodules. Results (1) There was no significant difference in lesion size between benign and malignant lesions(P>0.05). In the shape of lesions, benign lesions were significantly less than those of malignant lesions with spherical, lobulated and irregular shapes, P<0.05).(2) There was less burr and lobulation than malignant lesions on the edge of the lesion, and the boundary between the lesions was more clear than the malignant lesion, and the difference was statistically significant. (P<0.05). (3) the PET/CT - SUVmax value between the benign and malignant lesionshas no obvious difference, P> 0.05.(4) compared with malignant lesions, the average CT value and peak value of benign lesions were significantly higher, P<0.05). Conclusion Multi slice spiral CT is effective in the diagnosis of focal pulmonary ground glass density nodules, and has high accuracy in determining the nature of fGGO lesions.