目的探讨动脉自旋标 记(arterial spin labeling， ASL ) 联合表观扩散系数 ( apparent diffusioncoefficient，ADC)在恶性胶质 瘤真假性进展鉴别诊断价值。方法 回顾 性分析15例恶性胶质瘤真性进展，7例假 性进展患者的临床及影像资料，比较异常 强化区与对侧正常区的脑血流量图(CBF 图)、表观扩散系数值(ADC)。结果 ASL示 真性进展呈高灌注，假性进展呈低灌注； 真假性进展ADC值差异无统计学意义。结 论 ASL对恶性胶质瘤真假性进展鉴别有一 定价值。

Objective To explore the application of a combination of arterial spin labeling(ASL) and apparent diffusion coefficient (ADC) for differentiating true progression from pseudoprogression of malignant glioma. Methods The clinical and imaging data of 15 cases of true progression and 7 cases of pseudoprogression were retrospectively analyzed. The image of relative cerebral blood flow (CBF) and the values of apparent diffusion coefficient(ADC)were compared between abnormal enhancement area and contralateral normal area. Results High perfusion were shown in ASL in the patients with true progression, low perfusion in ASL in the patients with pseudoprogression. there were no statistical differences in ADC values between true progression and pseudoprogression. Conclusion ASL is valuable in differentiating true progression and pseudoprogression.