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128层螺旋CT血管成像在周围动脉闭塞性疾病诊断中的临床应用价值研究

作者:宋留存1 李香芬1 陆普选2

所属单位:1.河南省郑州市第六人民医院 (河南 郑州 450015) 2.深圳市第三人民医院 (广东 深圳 518100)

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摘要

目的评价128层螺旋CT血管成 像在周围动脉闭塞性疾病诊断中的临床 应用价值。方法 前瞻性获取21例下肢动 脉闭塞性疾病患者(42侧肢体),平均年 龄(71±12.7)岁,获得知情同意后在东 芝Aquilion One 128层螺旋CT上进行下 肢动脉CTA检查(造影剂:碘帕醇370mgI/ mL(Iopamidol,BRACCO),双相注射,造 影剂剂量按体重分组),原始图像经过 VR、MIP、CPR后处理后获得重建图像。 其中有12例共12侧下肢在CTA检查后1周 内行DSA检查。由两位有经验的放射科医 生共同分析评价CTA显示双下肢各支动 脉段图像质量情况及各段狭窄程度,并 与DSA比较。结果 21例患者均顺利完成 双下肢动脉CTA检查,图像显示度评分为 (2.86±0.351)分,CTA静脉重叠评分为 (0.14±0.467)分,共有38侧下肢CTA未 发生静脉污染,占90.48%(38/42);4侧 下肢CTA发生不同程度的静脉强化,占 9.53%(4/42)。以DSA为金标准,CTA显示 动脉正常及轻度狭窄的敏感性96.30%, 特异性98.04%,阳性预测值98.73%,阴 性预测值94.33%。结论 128层螺旋CT能 够全面清晰显示双下肢动脉病变,为疾 病诊断提供快速、有效且可靠的诊断手 段,对临床诊断和治疗具有重要指导意 义。

Objective To evaluate the diagnostic value of 128-MDCT angiography inperipheral arterial occlusive disease. Methods Prospective for 21 patients with lower extremity artery occlusive disease (42 side body), average age (71±12.7), and obtain informed consent in Toshiba Aquilion One 128 layer spiral CT on lower limb arterial CTA (contrast agents: iodine 370 mgi palmer alcohol/mL (Iopamidol, BRACCO), bipolar, injection contrast medium dose groups by weight), the original image through VR, MIP, CPR image post-processing after reconstruction. A total of 12 patients with 12 lower limbs underwent DSA examination within 1 week after CTA examination. Two experienced radiologists were employed to analyze and evaluate the image quality and stenosis degree of each artery segment of the lower limb shown by CTA, and compared with DSA. Results 21 patients were successfully completed the double lower limb artery CTA examination, image display score was (2.86±0.351), CTA venous overlap score was (0.14±0.467)points, a total of 38 lower limb venous CTA without pollution, accounting for 90.48% (38/42). 4 lower limbs CTA of different degrees of venous enhancement, accounted for 9.53% (4/42). With DSA as the gold standard, CTA showed normal artery mild stenosis and a sensitivity of 96.30%, specificity of 98.04%, positive predictive value of 98.73%, negative predictive value of 94.33% showed obvious stenosis. Conclusion 128- MDCT can clearly show lower extremity arterial disease with important imformation for clinical diagnosis and treatment planning.

【关键词】周围动脉闭塞性疾病;CT血管成像;128层螺旋CT

【中图分类号】R322.1+2

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.08.045

前言

近年来,随着多探测器计算机断层扫描(MDCT)技术的不断进步和 发展,它具有扫描时间短、X射线辐射少、单体扫描覆盖范围广、造 影剂效应大等优点。为患者提供一种更好、更方便的检查方法[1]。128 MDCT有范围广泛的16厘米探测器,可以完全覆盖80%以上的成人和整个 儿童的实质器官和腔器官。但下肢血管范围大,扫描覆盖长度一般大 于1米,PAOD患者多为老年人,多伴有糖尿病、心力衰竭、动脉粥样硬 化等复杂的老年性疾病,如糖尿病、心力衰竭、动脉粥样硬化等。由 于患者性别、体重、心输出量不一致,因此下肢血流个体差异较大。 128 MDCT对冠状动脉、颅脑等CTA的研究[2]已有报道,而国内外关于双 下肢CTA的报道较少。本研究在21例患者中,评价128MDCT提供的下肢 动脉图像显示质量和狭窄诊断准确性,并和12例DSA相比较。