目的研究18F-FDG(氟代脱氧葡 萄糖)PETCT(正电子发射型计算机断层显 像)的最大标准摄取值(SUVmax)与PSA(前 列腺特异抗原)在前列腺癌(PCa)诊治中的 相关性。方法 选取我院诊治的37例经病 理学诊断确诊为前列腺癌的患者作为观 察组，收集28例良性前列腺增生患者作 为对照组。两组患者分别行PSA筛查以及 18F-FDG PETCT检查。以SUVmax>2.5、自 由PSA/总PSA(f/t)<0.16作为诊断前列腺 癌标准。研究人员对两组患者经18F-FDG PETCT生成的图像中放射性分布阳性病灶 进行感兴趣区测量，计算SUVmax。统计分 析SUVmax与PSA相关性。结果 观察组37例 tPSA 4-10ng/mL者28例，tPSA>10ng/mL者 9例；对照组28例患者中，tPSA 4-10ng/ mL者17例，tPSA<4ng/mL者11例。观察组 f/t显著低于对照组；观察组SUAmax显著 高于对照组。经相关性分析，SUVmax与 fPSA正相关(t=0.877，P<0.05)；SUVmax 与f/t负相关(t=0.988，P<0.05)。结论 SUVmax与fPSA正相关，SUVmax与f/t负相 关，对于处于诊断灰区的前列腺疾病患 者，SUVmax结合f/t可显著提高诊断前列 腺癌的准确率。

Objective To study the collelation between the 18F-FDG (FDG) PETCT (positron emission tomography) maximum standardized uptake value (SUVmax) and PSA (prostate specific antigen) in the diagnosis and treatment of prostate cancer. Methods A total of 37 cases which diagnosed of prostate cancer were selected as the observation group, and 28 cases of benign prostatic hyperplasia patients as a control group. Two groups of patients underwent PSA screening and 18F-FDG PETCT inspection. In SUVmax> 2.5, free PSA / total PSA (f/t) <0.16 as the standard diagnosis of prostate cancer. Researchers two groups of patients by 18F-FDG PETCT generated image of radioactivity distribution of positive lesions ROI measurement, calculation SUVmax. Statistical analysis SUVmax correlation with PSA. Results 37 cases tPSA 4-10ng/mL in 28 cases, tPSA> 10ng / mL in 9 cases, control group of 28 patients, tPSA 4-10ng/mL in 17 cases, tPSA <4ng/ mL in 11 cases. Observer Group f/t significantly lower than the control group. SUAmax observation group was significantly higher. After correlation analysis, SUVmax and fPSA positive correlation (t=0.877, P<0.05). SUVmax with f/t negative correlation (t=0.988, P <0.05). Conclusion SUVmax positively correlated with fPSA, SUVmax with f/t negative correlation for patients with prostate disease in diagnostic gray zone, SUVmax combined with f/t can significantly improve the accuracy of diagnosis of prostate cancer.