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MRI诊断宫颈癌的临床价值

作者:彭保成1 李振玉1 孙长录1 刘 斌1 牛永超1 王恩锋2

所属单位:1.新乡市中心医院影像科(河南 新乡 453000) 2.河南省人民医院放射科(河南 郑州 450000)

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摘要

目的探讨MRI诊断宫颈癌的临 床价值。方法 回顾性分析2013年05月至 2016年04月于我院妇产科行盆腔MRI检查 的224例疑似宫颈癌初诊患者的临床资 料,通过分析其MRI图像,观察比较MRI 诊断与术后病理学诊断宫颈癌及宫旁浸 润、阴道受侵、淋巴结转移的灵敏度、 特异度、阳性预测值、阴性预测值、准 确率,同时比较MRI分期与手术-病理分 期及术前临床分期准确性。结果 以术后 病理学检查为金标准,MRI诊断宫颈癌灵 敏度为97.06%,特异度为80.0%,MRI诊 断宫旁浸润的灵敏度为80.0%,特异度为 96.20%,MRI诊断阴道受侵的灵敏度为 87.72%,特异度为93.88%,MRI诊断淋 巴结转移的灵敏度为89.04%,特异度为 96.18%,MRI分期和手术病理分期与术 前临床分期比较,差异具有统计学意义 (χ2 =14.394和14.595,P<0.05),而MRI 分期与手术病理分期比较无显著性差异 (χ2 =0.198,P>0.05)。结论 MRI对于宫 颈癌诊断准确率高,在宫旁浸润、阴道 受侵及淋巴结转移具有较高灵敏度和特 异性,与术后病理相比,MRI对宫颈癌分 期准确度较高,可以为宫颈癌诊断和治 疗提供理论依据。

Objective To explore the clinical value of MRI in the diagnosis of cervical cancer. Methods The clinical data of 224 patients with suspected cervical cancer treated with pelvic MRI examination in the obstetrics and gynecology department of our hospital from May 2013 to April 2016 were analyzed retrospectively. Through the analysis of the MRI image, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of cervical cancer and uterine infiltration, vaginal invasion and lymph node metastasis were observed and compared by MRI diagnosis and postoperative pathological diagnosis. The accuracy of MRI staging and surgical pathological staging and preoperative clinical staging were also compared. Results Postoperative pathological examination was taken as the gold standard, and the sensitivity and specificity were respectively 97.06% and 80% in the cervical cancer, and 80% and 96.20% in the uterine infiltration and 87.72% and 93.88% in the vaginal invasion and 89.04% and 96.18% in the lymph node metastasis by MRI diagnosis. The differences were statistically significant in the comparison of MRI staging and surgical pathological staging and preoperative clinical staging (χ2 =14.394 and 14.595, P<0.05), but the comparison of MRI staging and surgical pathological staging was not statistically significant (χ2 =0.198, P>0.05). Conclusion MRI has high accuracy in the cervical cancer diagnosis and high sensitivity and specificity in the determination of uterine infiltration, vaginal invasion and lymph node metastasis. Compared with postoperative pathology, MRI has higher accuracy in the cervical cancer staging, and can provide theoretical basis for cervical cancer diagnosis and treatment.

【关键词】MRI;诊断;宫颈癌;分期

【中图分类号】R711.74

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.08.035

前言

宫颈癌是一种以高发病率和死亡率为主要特征的妇科恶性肿瘤, 根据世界卫生组织数据显示,全世界每年新增50万宫颈癌病例,而我 国每年新增宫颈癌病例高达13.5万,占据全球发病人数首位,每年因 宫颈癌死亡人数高达8万,严重危险广大女性的生命健康[1]。近年来, 随着医疗诊断技术的提高,宫颈癌年发病率虽出现下降,但患者发病 年龄表现出年轻化趋势,肿瘤治疗不仅关系患者生存时间同时与患者 生活质量密切相关[2]。手术-病理分期作为恶性肿瘤分期主要标准之 一,其中宫颈癌主要采用国际妇产科联盟(FIGO)系统进行临床分期, 需要患者丰富临床经验,同时需结合患者影像学资料及相关检查来判 断分期,其准确性较差,在宫旁浸润、宫颈间质浸润和淋巴结转移判 断较为困难[3]。磁共振成像(MRI)技术具有高分辨率、多参数、多方位 成像等特点,清楚显示肿瘤病变大小、位置及浸润程度,在肿瘤分期 中应用逐渐增多[4]。研究显示,MRI在宫颈癌诊断方面具有一定优势, 能够为临床宫颈癌的诊断和治疗提供参考价值[5]。本研究通过探讨MRI 技术在宫颈癌的诊断价值,探讨MEI技术在宫旁浸润、淋巴结转移和阴 道受侵等方面灵敏度、特异度、阳性预测值、阴性预测值和准确度, 现报道如下。