目的探讨周围型非小细胞肺癌 (non-small cell lung cancer，NSCLC) 的CT特征与表皮生长因子受体(epidermal growth factor receptor, EGFR)基因 突变的相关性。方法 回顾性分析288例 经手术证实周围型NSCLC的CT征象和临 床资料，采用Logistic回归分析确定 与EGFR基因突变相关的危险因素。结 果 288例周围型NSCLC中，EGFR基因突变 型148例(51.4%)。Logstic回归分析显 示性别、肿瘤的质地和胸膜凹陷征为与 NSCLC的EGFR基因突变相关的独立危险因 素，OR值分别为2.875(95% CI，1.455- 5.682)、0.535(95% CI，0.349-0.821)和 2.597(95% CI，1.236-5.455)。CT特征联 合临床资料对NSCLC的EGFR基因突变预测 的AUC为0.642。结论 性别、肿瘤的质地 和胸膜凹陷征等临床和CT特征为与周围 型NSCLC的EGFR基因表型相关的独立危险 因素，CT特征结合临床资对EGFR基因突 变有一定的诊断价值

Objective To investigate the association between CT characteristics of peripheral non-small cell lung cancer (NSCLC)and epidermal growth factor receptor(EGFR) gene mutation. Methods Clinical presentations and CT characteristics of 288 consecutive patients with pathological confirmed peripheral NSCLC were retrospectively reviewed. Logistic analysis was used to determine the association of clinical presentations and CT characteristicswith EGFR gene mutation. Results In the 288 patients, there were 148 patients with EGFR mutations (51.4%). Logistic analysis identified that gender (Odds Ratio:2.875[95% CI,1.455-5.682]) , tumor's texture (Odds Ratio: 0.535[95% CI，0.349- 0.821]) and pleural retraction (2.597[95% CI, 1.236-5.455]）were risk factors for EGFR gene mutation. Conclusion Gender, tumor's texture and pleural retraction were association with EGFR gene mutation in peripheral NSCLC. Combination CT characteristics and clinical presentation were useful for identified EGFR genotype of peripheral NSCLC.