目的 探究动态增强磁共振成像 (DCE-MRI)在直肠癌患者术前中的应用。 方法 收集2015年12月-2017年12月于信阳 市中心医院肿瘤外科诊治的240例直肠癌 患者MRI常规及DCE-MRI扫描图像进行回顾 性分析，将患者容量转移常数(Ktrans)、速 率常数(Kep)、EES容积比(Ve)参数结果与 肿瘤病理分化程度、Dukes分期、TNM分 期及淋巴结转移情况进行对比分析。结 果 Ktrans随肿瘤病理分化程度降低、Dukes 分期增加、TNM分期增加及淋巴结转移而 显著升高，差异有统计学意义(P<0.05)； Kep、Ve在病理分化程度、Dukes分期、TNM 分期及淋巴结转移的差异比较无统计学意 义(P>0.05)。结论 DCE-MRI可较好地反映 肿瘤内部血流动力学情况，其参数Ktrans值 与病理分化程度、Dukes分期、TNM分期及 淋巴结转移具一定相关性，对直肠癌术前 评估具重要应用价值。

Objective To explore the preoperative application of dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) in patients with rectal cancer. Methods The scan images of MRI routine and DCE-MRI of 240 patients with rectal cancer treated in department of oncology at Xinyang Central Hospital from December 2015 to December 2017 were collected for retrospective analysis. The capacity transfer constant (Ktrans), rate constant (Kep) and EES volume ratio (Ve) were analyzed and compared with tumor pathological differentiation, Dukes stage, TNM stage and lymph node metastasis. Results Ktrans was increased significantly with the decreased tumor pathological differentiation, increased Dukes stage and TNM stage and lymph node metastasis (P<0.05). There was no significant difference in pathological differentiation, Dukes stage, TNM stage and lymph node metastasis between Kep and Ve (P>0.05). Conclusion DCE-MRI can better reflect the hemodynamics within tumor, and its Ktrans value is correlated with the pathological differentiation, Dukes stage, TNM stage and lymph node metastasis, and it has important application value for preoperative evaluation of rectal cancer.