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磨玻璃密度肺结节 的CT影像学特征及 其与病理特征的相 关性研究

作者:张茜茜 杨会珍 李晓亮 陈卓昌

所属单位:河南省人民医院呼吸及危重症科 (河南 郑州 450003)

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摘要

目的 分析磨玻璃密度肺结节的 CT影像学特征及其与病理特征的相关性。 方法 将2015年1月-2017年12月间于我院 行CT检查有磨玻璃密度肺结节的86例患者 纳入研究范围,回顾性分析其CT影像学资 料,包括病灶位置、大小、形态、边界、 边缘、内部结构特点、周围结构特点等。 结果 86例患者均为单发病灶,纯磨玻璃 肺结节35例,混杂磨玻璃肺结节51例,肺 癌或癌前病变占比65.12%(56/86),良性 病变占比34.88%(30/86);良性病变中边 界模糊病例显著高于肺癌或癌前病变,边 界清晰毛糙状病例、病灶边缘分叶、毛刺 病例显著低于肺癌或癌前病变,胸膜凹陷 征、血管集束征病例显著低于肺癌或癌 前病变,小叶间隔增厚病例显著高于肺 癌或癌前病变,差异均有统计学意义(P ﹤0.05);但良恶性病变在病灶位置、大 小、形态、边界光滑、支气管充气征、含 气腔隙等CT征像表现差异无统计学意义(P ﹥0.05)。结论 良恶性磨玻璃结节病灶在 病灶边界,边缘、周围结构上有一定差异 性,或能为良恶性磨玻璃密度肺结节的诊 断鉴别提供参考依据。

Objective To analyze the CT imaging characteristics of pulmonary ground glass density nodules and their correlation with pathological features. Methods 86 patients with pulmonary ground glass density nodules examined by CT in the hospital from January 2015 to December 2017 were enrolled in the study, and their CT imaging data, including the location, size, shape, boundary, internal structure and surrounding structure were analyzed retrospectively. Results Lesion of the 86 patients were single lesions. 35 cases were pure pulmonary ground glass nodules and 51 cases were pulmonary ground glass nodules. Lung cancer or precancerous lesions accounted for 65.12%(56/86), and benign lesions accounted for 34.88% (30/86).The proportion of fuzzy boundary in benign lesionswas significantly higher than that inlung cancer or precancerous lesions, while proportions of clear and coarse boundary,lobulation of lesions edge and spiculation were significantly lower than those in lung cancer or precancerous lesions. The proportions of pleural indentation and vascular convergence sign in benign lesions were significantly lower than those in lung cancer or precancerous lesions, while the proportion of interlobular septal thickening was significantly higher than that in lung cancer or precancerous lesions(P<0.05). However, there was no significant difference in CT signs, such as the location, size, shape, smooth boundary, air bronchogram and lacuna containing airbetween benign and malignant lesions (P>0.05). Conclusion There are differences between benign and malignant ground glass nodules in the boundary, edge and surrounding structure of lesions, which can provide references for diagnosis and differential diagnosis of benign and malignant ground glass nodules.

【关键词】磨玻璃密度肺结节;CT影像学 特征;病理特征;相关性研究

【中图分类号】R521

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2018.06.005

前言

经CT影像学诊断后漏诊的肺癌中,有高达69%漏诊患者的CT影像学 存在磨玻璃密度影成分,系在CT肺窗内以肺内局灶性云雾状结节样密 度轻度增加影,边界或清或欠清,但病灶内仍可见血管及支气管血管 纹理,是肺内常见且非特异性的高分辨计算机断层显像征像[1]。而CT 作为胸部诊断肺内小结节的首选诊断方式,磨玻璃病灶的检测、识别 仍基于检验医师对肺密度的主观评价,因此,充分明确磨玻璃密度肺 结节的CT影像特征及其与病理特征的相关性于良恶性磨玻璃密度结节 的高效诊断鉴别尤为重要[2-3],鉴于此,现采集资料拟以回顾性方式对 磨玻璃密度结节的CT影像学特点进行分析,并研究其与病理特征的相 关性,具体报道如下。