目的 探讨螺旋CT灌注技术联合 生化指标检测在急性胰腺炎诊断及病情 评估中的应用价值。方法 回顾性分析我 院2014年1月-2017年6月收治的84例AP患 者临床资料。根据Balthazar 分级标准 将患者分为5 组，1组17例、2组16例、3 组18例、4组17例、5组16例。应用螺旋 CT扫描获得灌注参数，使用ELISA及速率 法检测生化指标。结果 随着病情的进展 AP患者BF、BV逐渐下降，1组、2组、3 组、4组、5组患者的BF、BV比较有差异 (P<0.05)，有统计学意义；MTT、PS未见 明显变化，1组、2组、3组、4组、5组患 者的MTT、PS比较无差异(P>0.05)，无统 计学意义。1组、2组、3组、4组、5组患 者S-Amy、CRP、U-Amy、HCT比较有差异 (P<0.05)，有统计学意义。分析发现， S-Amy、U-Amy、CRP与BF、BV、MTT、PS存 在相关性，不具统计学意义(P>0.05)，无 统计学意义；HCT与BF、BV之间呈现负相 关(P<0.05)，有统计学意义；与MTT、PS 无明显相关性(P>0.05)，无统计学意义。 结论 早期AP的CT灌注参数BF、BV随病情 发展而降低，S-Amy、U-Amy生化指标升 高，重症AP时S-Amy、U-Amy下降。HCT与 BF、BV之间为负相关，是反映胰腺微循环 的重要指标，有利于预后。

Objective To investigate application value of spiral CT perfusion technology combined with biochemical indexes in the diagnosis and condition evaluation of acute pancreatitis (AP). Methods The clinical data of 84 AP patients admitted from January 2014 to June 2017 in our hospital were retrospectively analyzed. The patients were divided into 5 groups according to the Balthazar classification. Group 1 consisted of 17 patients, 16 patients in Group 2, 18 patients in Group 3, 17 patients Group 4 and 16 patients Group 5. The perfusion parameters were obtained by spiral CT scan, and the biochemical indexes were detected by ELISA and rate assay. Results BF and BV decreased gradually with the progress of AP, and the BF and BV in Group 1, Group 2, Group 3, Group 4 and Group 5 were significantly different, with statistical significance (P<0.05). There was no significant change in MTT and PS, and the MTT and PS in Group 1, Group 2, Group 3, Group 4 and Group 5 had no significant difference (P>0.05). The levels of S-Amy, CRP, U-Amy and HCT in Group 1, 2, 3, 4 and 5 were significantly different, with statistical significance (P<0.05). The results showed that the correlation between S-Amy, U-Amy, CRP and BF, BV, MTT and PS was not statistically significant (P>0.05). HCT was negatively correlated with BF and BV, with statistical significance (P<0.05), but had no significant correlation with MTT and PS (P>0.05). Conclusion In early-phase AP, the CT perfusion parameters of BF and BV decreased with the development of the disease, and the biochemical indexes of S-Amy and U-Amy increased. While S-Amy and U-Amy decreased in severe AP, suggesting that there is a negative correlation between HCT and BF and BV, which is an important indicator of pancreatic microcirculation and is conducive to prognosis.