目的 探讨3.0T磁共振全身扩 散加权成像(whole-body diffusion weighted imaging, WB-DWI)的最佳成像 参数。方法 选择30例健康志愿者、30例 恶性肿瘤患者行WB-DWI扫描，将以上被检 查者随机分为4组，每组15例。主要扫描 参数：第1组采用体线圈、STIR-EPI、b值 =800s/mm2 ，第2组采用相控阵表面线圈、 STIR-EPI、b值=800s/mm2 ，第3组采用相 控阵表面线圈、SPAIR-EPI、b值=800s/ mm2 ，第4组采用相控阵线圈、STIR-EPI、 b值=400s/mm2 。对所有图像进行图像质 量评分，比较不同扫描参数下的WB-DWI 图像质量。结果 相控阵表面线圈扫描的 图像质量明显优于体线圈(P＜0.01)； STIR-EPI的图像质量优于SPAIR-EPI(P ＜0.05)；b=400s/mm2 与b=800s/mm2 时， 图像质量无显著差异(P＞0.05)。结论 采 用相控阵表面线圈、STIR-EPI、b=800s/ mm2 、FOV 40cm×40cm、TR=8000ms，并且 呼吸均匀时获得的WB-DWI图像质量最好， 扫描时间适中。

Objective To investigate the best imaging parameters of 3.0T MR whole-body diffusion weighted imaging (WB-DWI). Methods 30 healthy volunteers and 30 patients with malignant tumor underwent WB-DWI scan. The patients were randomly divided into 4 groups, 15 patients in each group. Main scanning parameters: The first groups using body coil, STIR-EPI, b=800s/mm2 , the second groups using phased array surface coil, STIR-EPI, b=800s/mm2 , the third groups using phased array surface coil, SPAIR-EPI, b=800s/mm2 , the fourth groups using phased array coil, STIR-EPI, b=400s/mm2 . Make an image quality score for all images, Compare the quality of WB-DWI images under different scanning parameters. Results The image quality of phased array surface scan is obviously better than that of body coil (P<0.01), the image quality of STIR-EPI is better than that of SPAIR-EPI (P<0.05), the image quality is not significantly different when the b=400s/mm2 and b=800s/mm2 (P>0.05). Conclusion Using phased array surface coils, STIR-EPI, b=800s/mm2 , FOV 40cm×40cm, TR=8000ms, and breathing evenly, the WB-DWI images have the best quality and moderate scanning time.