目的 探讨超声与磁共振成像 (MRI)在产前诊断胎儿畸形中的价值。 方法 选取466例经产前超声诊断提示异 常或可疑异常胎儿，均接受MRI检查， 并以产后随访结果为对照，评价超声与 MRI对胎儿畸形的诊断符合率。结果 466 例胎儿异常中，以神经系统畸形最为常 见(44.21%)，其余依次为泌尿生殖系统 畸形(18.24%)、胸部畸形(13.95%)、消 化系统畸形(7.30%)、胎儿水肿与肿瘤 (6.22%)、骨骼系统及肢体畸形(3.86%)、 心脏畸形(3.22%)、腹壁缺陷(2.36%)、 颜面异常(0.64%)；与尸检及随访结果 对照，MRI诊断胎儿畸形的总符合率为 94.42%(440/466)，明显高于超声诊断的 85.00%(396/466)，差异有统计学意义 (P<0.05)；胎儿畸形检出时孕周分布： 396例超声确诊的胎儿异常者中，35例 (8.84%)发现于孕<18周，153例(38.64%) 发现于孕18-24周，136例(34.34%)发现 于孕25-30周，72例(18.18)发现于孕>30 周。结论 超声、MRI均对胎儿畸形有重要 诊断价值，以超声为主要筛查手段，合理 运用MRI，有助于提高诊断符合率。

Objective To investigate the value of ultrasonography and magnetic resonance imaging (MRI) in prenatal diagnosis of fetal malformation. Methods A total of 466 fetuses with abnormalities or suspicious abnormalities diagnosed by prenatal ultrasonography selected and were examined by MRI. With the results of follow-up after birth as control, the diagnostic accordance rates of fetal malformation by ultrasonography and MRI were compared. Results In 466 cases of fetal abnormalities, the nervous system malformation was the most common (44.21%), followed by genitourinary system malformation (18.24%), chest deformity (13.95%), digestive system abnormalities (7.30%), fetal edema and tumor (6.22%), skeletal system and limb deformities (3.86%), heart malformations (3.22%), abdominal wall defects (2.36%) and facial anomalies (0.64%). Compared with results of autopsy and follow-up, the total accordance rate of MRI diagnosis of fetal malformation was 94.42% (440/466), which was significantly higher than that of ultrasound diagnosis [85.00% (396/466)] (P<0.05). Among 396 cases diagnosed with fetal abnormalities, 35 cases (8.84%) were found within 18 weeks of gestation, 153 cases (38.64%) were found in 18-24 weeks of gestation, 136 cases (34.34%) were found in 25-30 weeks of gestation and 72 cases (18.18) were found after 30 weeks of gestation. Conclusion Both of ultrasonography and MRI are of certain value in the diagnosis of fetal malformation. Using ultrasonography as the main screening method and rational use of MRI are helpful to improve the diagnostic accordance rate.