目的 探讨MRI扩散加权成像成像 (diffusion weighted imaging,DWI)及动 态增强时间-信号强度曲线(TIC)在乳腺良 恶性病变鉴别诊断中的影像学表现特点， 以提高诊断准确率,避免误诊。方法 回顾 分析52例经病理确诊的63个乳腺病变患 者的临床和影像资料，将常规MRI、DWI 及TIC对比分析，评价DWI联合TIC在乳腺 良恶性病变鉴别诊断的优越性。结果 乳 腺良恶性病变的表观扩散系数(apparent diffusion coefficient,ADC)值差异有统 计学意义(P<0.05)；良恶性病变的各TIC 分型差异有统计学意义(P<0.05)；两者联 合诊断与ADC或TIC单独诊断，其敏感性、 特异性及准确率差异有统计学意义(均 P<0.05)。结论 ADC值联合TIC能够协助诊 断乳腺良恶性病灶，较单一指标单独应用 具有更大的诊断价值。

Objective To explore the imaging features of MRI diffusion weighted imaging (DWI) and dynamic enhanced Time-Signal intensity curve (TIC) in the differential diagnosis of benign and malignant breast lesions, so as to improve the diagnostic accuracy and avoid misdiagnosis. Methods The clinical and imaging data of 52 patients with pathologically confirmed breast lesions were retrospectively analyzed. Conventional MRI, DWI and TIC were compared to evaluate the superiority of DWI combined with TIC in differential diagnosis of benign and malignant breast lesions. Results The apparent diffusion coefficient of benign and malignant breast lesions was significantly different (P<0.05). The difference of TIC in benign and malignant lesions was statistically significant (P<0.05). The sensitivity, specificity and accuracy of joint diagnosis with ADC or TIC were significantly different (all P<0.05). Conclusion ADC value combined with TIC can assist in the diagnosis of benign and malignant breast lesions, which is more valuable than single index alone.