目的 探究乳腺动态增强MRI定 量参数容量转移常数(volumetransfer constant，Ktrans)、血管外细胞外间隙 容积比(extravascular extracellular volume fraction，Ve)、速率常数(rate constant，Ke p)与免疫组化指标血管 内皮生长因子(vascular endothelial growth factors，VEGF)、微血管密度 (microvesseldensity，MVD)的相关性。 方法 该探究对象为2015年11月-2017年11 月于我院诊断的40例恶性乳腺疾病患者、 30例良性乳腺疾病患者以及30例非脂肪型 乳腺健康门诊者，设为恶性组、良性组与 对照组；均采用乳腺动态增强MRI扫查双 侧腋窝及乳房，记录三组Ktrans、kep、 Ve等MRI定量参数，免疫组化检测恶性 组、良性组乳腺病灶VEGF、MVD，并进行 与MRI定量参数的相关性分析。结果 恶性 组Ktrans、kep、Ve均显著高于良性组与对照 组，且良性组显著高于对照组，差异具有 统计学意义(P<0.05)；良性组VEGF、MVD 均显著高与对照组，差异具有统计学意义 (P<0.05）；Ktrans、Kep、Ve与VEGF、MVD均 呈正相关(P<0.05)。结论 Ktrans、kep、 Ve与VEGF、MVD均呈正相关,在乳腺疾病的 良恶性鉴别诊断中具有重要价值。

Objective To investigate correlation of quantitative parameters of dynamic contrast-enhanced MRI of the breast volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve), the rate constants (Kep) with immunohistochemical markers of vascular endothelial growth factor (VEGF), microvessel density (MVD). Methods 40 patients with malignant breast disease, 30 patients with benign breast disease and 30 patients with non-fat breast health clinic diagnosed in our hospital from November 2015 to November 2017 were classified as malignant group, benign group and control group. Patients were screened by dynamic mammary gland MRI for bilateral armpits and breasts. MRI quantitative parameters such as Ktrans, Kep and Ve were recorded. Immunohistochemistry was used to detect VEGF and MVD of breast lesions in the malignant group and benign group, and the correlation between MRI and quantitative parameters was analyzed. Results Ktrans, Kep and Ve in malignant group were significantly higher than those in benign group and control group, and were significantly higher in benign group than in control group (P<0.05). The VEGF and MVD in the benign group were significantly higher than those in the control group, the difference was statistically significant (P<0.05). Ktrans, Kep and Ve were positively correlated with VEGF and MVD (P<0.05). Conclusion Ktrans, Kep and Ve are positively correlated with VEGF and MVD, and have important value in differential diagnosis of benign and malignant breast diseases.