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中枢神经细胞瘤影 像学表现及病理分 析

作者:杨艳秋1 陈自谦2 汪 丽1

所属单位:1.福建医科大学福总临床医学院 (福建 福州 350000) 2.南京军区福州总医院 (福建 福州 350025)

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摘要

目的 探讨中枢神经细胞瘤(CNC) 的影像及病理表现,以提高其诊断准确 率。方法 回顾性分析11例经手术病理证 实的CNC患者的临床、影像资料及病理表 现。结果 11例行MRI检查,4例行CT平 扫。10例肿瘤位于侧脑室,邻近Monro 孔,与透明隔宽基底相连。CT及MRI上 肿瘤为囊实性,呈“海绵征”或“皂泡 征”;CT上3例病灶内见不同程度钙化;9 例病灶边缘与侧脑室壁之间见多发实性条 索影;增强8例呈轻-中度强化,3例呈不 均匀明显强化,7例病灶内部及周边见强 化血管影。10例均伴有不同程度侧脑室积 水。另1例位于左侧额颞叶。结论 中枢神 经细胞瘤临床、影像及病理学表现有一定 特征性,结合发病年龄及典型特点,有助 于与其它脑室内肿瘤鉴别。

Objective To investigate the imaging appearances and pathological features of Central Neurocytoma (CNC) in order to improve diagnostic accuracy. Methods 11 cases with CNC which were confirmed by surgery and pathology were retrospectively analyzed with imaging and pathological findings. Results 11 patients received MRI examination and of which 4 cases also underwent CT scans. 10 lesions located in lateral ventricle, near the foramen of Monro, and were attached to the septum pellucidum with a broad base. On CT and MRI tumors showed cystic-solidary, which was called"sponge sign" or "soap bubble sign". 3 cases presented calcification on CT. Multiple solid spicules between the edge of the lesions and the lateral ventricle wall were observed in 8 lesions. Postcontrast MRI revealed mild to moderate enhancement in 8 cases, 3 cases showed inhomogeneous obviously enhancement.7 cases were found enhanced vessels in the internal or peripheral of the lesions. 10 cases were accompanied with different degrees of hydrocephalus. Only 1 case in the left frontal and temporal lobes. Conclusion Central Neurocytomas had certain characteristics in clinical, imaging and pathological manifestations. Combined with the onset age and typical location may helpful to the diagnosis and differentiation from other tumors residing in lateral ventricle.

【关键词】中枢神经细胞瘤;磁共振成 像;计算机体层摄影术

【中图分类号】R739.41;R445.2;R445.3

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.09.003

前言

中枢神经细胞瘤(central neurocytoma,CNC)是一种分化良 好的颅内偏良性肿瘤,其发病率低,占原发中枢神经系统肿瘤的 0.1%~0.5%[1],因其与少突胶质细胞瘤病理表现相似,曾被误诊为少 突胶质细胞瘤。本文回顾性分析11例CNC患者的临床影像资料并结合病 理,探讨其影像学表现,以提高术前诊断准确率。