目的 探索核磁ADC值与灌注成 像相对血流量(r CBF)和相对血容量(r CBV)在鉴别原发性中枢神经系统淋巴瘤 (PCNSL)与胶质母细胞瘤(GBM)的意义， 提高对两种疾病的诊断准确率。方法 选 取2012年9月至2016年9月经本院病理证 实的93例原发性中枢神经系统淋巴瘤与 胶质母细胞瘤MRI平扫与动态增强数据。 通过后处理软件选择动态增强图像中选 择感兴趣区，测量相对血流量(r CBF)、 相对血容量(r CBFV)及病灶ADC值，并对 测量数据对PCNSL与GBM进行对比分析。 结果 PCNSL信号均匀，弥散受限，明显 强化或不均质性强化，周围可见水肿。 GBM信号不均，实性部分弥散受限，多数 呈不规则性强化，周围大片水肿。PCNSL 的ADC值低于GBM，且差异具有统计学意 义(P＜0.05)。PCNSL与GBM病灶r CBF与 r CBV发现，PCNSL的r CBF(2.52±0.75) 和 r C B V ( 3 . 5 7± 0 . 9 3 )低于 G B M的 r CBF(5.15±1.05)和r CBV(7.95±1.97)， 且差异具有统计学意义(P＜0.05)。结论 根据ADC值和r CBF和r CBV能够进行有效 鉴别，在临床鉴别PCNSL与GBM具有重要的 临床意义，能够提高PCNSL与GBM的诊断准 确率。

Objective To explore the apparent diffusion coefficient(ADC), relative blood flow(r CBF) and relative blood volume(r CBFV) in diagnosis of primary central nervous system lymphoma(PCNSL) and glioblastoma multiforme(GBM), in order to improve the accuracy of the diagnosis of both diseases. Methods The MRI data of 93 cases were selected in histologically confirmed with PCNSL and GBM. By choosing the dynamic contrast enhanced image in post-processing software. And measurement and analysis of the ADC, r CBF, and r CBFV. Results The lesion of PCNSL was signal even, restricted diffusion, enhancement or heterogenous enhancement, and peripheral edema. The apparent diffusion coefficient of PCNSL less than the GBM, and the difference was statistically significant(P＜0.05). The PCNSL of r CBF and r CBFV of is less than the GBM, and the difference was statistically significant(P＜0.05). Conclusion According to the apparent diffusion coefficient, r CBF and r CBFV could efficient identification the PCNSL and GBM. Clinical differential diagnosis of PCNSL and GBM has important clinical implications, will improve the accuracy of diagnosis of PCNSL and GBM.