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16例脑室内中枢神 经细胞瘤患者MRI误 诊分析

作者:刘 震1 张 萍2 张佩娟3 王 织1 宫若晨2

所属单位:1.山东省青岛中心医院分子影像 科MR室 (山东 青岛 266042) 2.山东省青岛中心医院放射科 (山东 青岛 266042) 3.山东省青岛中心医院科教科 (山东 青岛 266042)

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摘要

目的 总结16例脑室内中枢神经 细胞瘤患者的MRI表现并分析误诊原因及 鉴别要点。方法 将我院2009年1月至2014 年12月期间收治的术前MRI诊断为脑室内 中枢神经细胞瘤的16例患者的临床资料 (包括影像学资料及病理学资料)进行回顾 性分析,所有病例均行MRI平扫及增强扫 描。以手术病理结果为基准判断MRI诊断 结果,总结脑室内中枢神经细胞瘤患者 MRI,并对误诊患者的原因及鉴别要点进 行分析。结果 16例患者中,11例术前诊 断准确(8例位于侧脑室、2例位于三脑室 且累及室间孔、1例位于四脑室),5例误 诊(胶质细胞瘤2例、室管膜瘤1例、混合 型生殖细胞瘤1例、脑膜瘤1例)。可见邻 近透明隔或Monro孔,内部或边缘可见多 发囊变,大小不一、形态多样,可呈小囊 状、不规则或多房状大囊变。多以实性 为主,可见囊变。实性部分T1WI等或稍低 信号、T2WI等或稍高信号;囊性部分T1WI 低信号,T2WI高信号。部分患者伴出血、 瘤灶周围脑水肿、脑室扩张积水及中线移 位。增强扫描病灶呈明显不均匀强化,囊 变、坏死钙化区无强化。结论 对发生于 脑室前部或靠近室间孔区的肿瘤患者,可 在符合MRI表现的基础上结合手术病理、 免疫组化标记进行鉴别诊断,降低误诊 率。

Objective To summarize the MRI findings of 16 cases of patients with intraventricular central neurocytoma and analyze the causes and identification of misdiagnosis. Methods The clinical data (including radiographic data and pathology data) of 16 cases of patients diagnosed with intraventricular central neurocytoma by preoperative MRI in our hospital from January 2009 to December 2014 were retrospectively analyzed. All patients were performed MRI plain scan and enhanced scan. The MRI findings were judged on the basis of surgical and pathological findings, and the MRI of patients with intraventricular central neurocytoma was summarized, and the causes and identifications of misdiagnosed patients were analyzed. Results Among 16 patients, there were 11 cases with preoperative correct diagnosis (8 cases in the lateral ventricle, 2 cases in the third ventricle involving the interventricular foramen, 1 case in the fourth ventricle) and 5 cases with misdiagnosis (2 cases of glioma, 1 cases of ependymoma, 1 case of mixed germ cell tumor, 1 case of meningioma). There were adjacent septum pellucidum or Monro hole and multiple cystic lesions in the internal or edge, which varied in size, shape, and might be small cystic, irregular or multilocular cystic lesions. There were mostly solid parts, and visibly cystic lesions. The solid part of the T1WI was with slightly lower signal and T2WI was with slightly higher signal. The cystic part of T1WI was with low signal and T2WI was with high signal. Some patients were accompanied by hemorrhage, the tumor surrounding brain edema, the ventricles dilatation and the midline displacement. The enhanced scan showed there were obvious inhomogeneous enhancement in the lesions and no enhancement in the cystic lesions and necrosis in calcification area. ConclusionFor patients with tumors in the anterior ventricles or near the interventricular foramen, it is possible to make differential diagnosis with the combination of surgical pathology and immunohistochemical markers on the basis of the MRI findings, thus reducing the rate of misdiagnosis.

【关键词】脑室内;中枢神经细胞瘤; MRI;误诊;囊变

【中图分类号】R445.2;R739.41

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.09.006

前言

中枢神经细胞瘤为神经系统的少见原发肿瘤,好发于侧脑室孟氏 孔区,主要来源于成熟神经元细胞,在原发性中枢神经系统肿瘤中所 占比例在0.25%~0.5%之间[1],患者以青年人居多。相关文献显示[2], 临床脑室内中枢神经细胞瘤与脉络丛乳头状瘤、脑室内脑膜瘤、胶质 瘤(星形细胞瘤、少突胶质细胞瘤等)等发生部位接近,影像学表现类 似,因而易混淆并导致误诊。2007年,世界卫生组织(World Health Organization,WHO)将中枢神经系统肿瘤划入WHOⅡ级肿瘤的范畴[3], 分为脑室内与脑室外两种类型。由于中枢神经细胞瘤的生物学特征呈 良性,预后良好,术前进行准确诊断是制定有效治疗方案,改善患者 预后的基础。鉴于此,本研究将我院收治的术前MRI诊断为脑室内中枢 神经细胞瘤的16例患者进行回顾性分析,总结16例脑室内中枢神经细 胞瘤患者的MRI表现并分析误诊原因及鉴别要点,现报道如下。