摘要
目的 研究冠状动脉CT血管成像 (CCTA)联合动态心电图(DCG)在诊断冠心 病(CHD)心肌缺血价值。方法 300例疑 似CHD患者行CCTA、DCG检测,并将核素心 肌灌注显像(MPI)结果作为金标准,评估 CCTA联合DCG诊断价值。结果 MPI诊断CHD 心肌缺血率61.67%,有204个心肌灌注异 常区域,其中固定性灌注缺损区29个,可 逆性灌注减低区175个;CCTA诊断心肌缺 血率63.67%,有224个收缩期心肌灌注异 常区,其中固定性灌注缺损27个,部分 可逆性灌注填充66个,可逆性灌注填充 131个;DCG诊断心肌缺血率52.67%,其 中ST段上斜型压低11例,下斜型压低33 例,水平型压低114例;CCTA联合DCG诊 断心肌缺血率66%;CCTA灵敏度83.78%, 特异度68.70%,阳性预测值81.15%,准 确性78%,Kappa值53%,DCG为71.35%、 77.39%、83.54%、62.68%、73.67%、 46.68%,CCTA联合DCG为94.59%、80%、 88.38%、90.20%、89%、79.23%。结论 CCTA和DCG用于冠心病心肌缺血诊断,均 有较佳诊断效能,但CCTA联合DCG诊断, 识别效果更佳,可提高诊断检出率。
Objective To study the value of coronary CT angiography (CCTA) and dynamic electrocardiogram (DCG) in the diagnosis of myocardial ischemia in coronary heart disease (CHD). Methods 300 cases of suspected CHD patients were given CCTA and DCG detection, and the results of radionuclide myocardial perfusion imaging (MPI) were taken as a gold standard to assess the diagnostic value of CCTA combined with DCG. Results CHD myocardial ischemic rate in MPI detection was 61.67% and there were 204 myocardial perfusion abnormal areas, including 29 fixed perfusion defect areas and 175 reversible perfusion reduction areas. Myocardial ischemic rate in CCTA diagnosis was 63.67% and there were 224 systolic myocardial perfusion abnormal areas, including 27 fixed perfusion defect areas, 66 partially reversible perfusion filling areas and 131 reversible perfusion filling areas. Myocardial ischemic rate in DCG diagnosis was 52.67%, and 11 cases upward sloping ST segment depression, 33 cases downward sloping depression and 114 cases horizontal depression were shown by DCG diagnosis. Myocardial ischemia rate in CCTA combined with DCG diagnosis was 66%. The rates of sensitivity, specificity, positive predictive value, accuracy, Kappa value were 83.78%, 68.70%, 81.15%, 78%, 53% in CCTA respectively and were 71.35%, 77.39%, 83.54%, 62.68%, 73.67%, 46.68% in DCG respectively, and were 94.59%, 80%, 88.38%, 90.20%,89%, 79.23% in CCTA combined DCG. Conclusion Both CCTA and DCG have good diagnostic efficacy in the diagnosis of myocardial ischemia in coronary heart disease, but CCTA combined with DCG diagnosis is better for recognition and can improve the diagnostic detection rate.
【关键词】冠心病;心肌缺血;CCTA; DCG;MPI
【中图分类号】R541.4
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2017.09.019
前言
冠心病(coronary atherosclerotic heart disease,CHD)主要由 冠状动脉粥样硬化病变所致,可诱发冠脉血管狭窄和心肌缺血,导致 心肌梗死、心力衰竭、猝死等,严重威胁患者生命安全,近年来研究 显示,冠心病发病的上升,最为相关的因素并非冠脉狭窄,而是心肌 缺血,心肌缺血被誉为诱发急性心血管病的罪魁祸首[1-3]。核素心肌灌 注显像(MPI)是诊断CHD心肌缺血的金标准,但因其存在辐射和诊断费 用昂贵,并不适于临床广泛推广[4]。动态心电图(DCG)诊断冠心病具有 无创、价廉、实用等特点;冠状动脉CT血管成像(CCTA)也属于无创诊 断冠心病手段,具有较高诊断灵敏度和阴性预测值,目前临床有关两 种检测方式联合诊断冠心病心肌缺血的报道较少[5-6]。本研究针对我院 300例疑似冠心病患者进行CCTA和DCG诊断,分析CCTA联合DCG诊断价 值,为冠心病心肌缺血诊断提供有价值参考。具体如下。
中国CT和MRI杂志
第15卷, 第 9 期
2017年09月
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