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论著-头颈部

胃肠道神经内分泌肿瘤的CT表现*

作者:何云飞1 罗宴吉2 黄 坤2 彭振鹏2 李子平2 冯仕庭2

所属单位:1.南方医科大学附属南海医院放射 科 (广东 佛山 528200) 2.中山大学附属第一医院放射科 (广东 广州 510080)

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摘要

目的 总结胃肠道神经内分泌肿 瘤的CT表现,提高GI-NEN的CT诊断水平。 方法 回顾性分析36例经手术病理证实的 GI-NEN的CT资料,观察内容包括病灶部 位、大小、生长方式、边界清晰否、浸润 性病灶管腔厚度、有无溃疡、有无坏死/ 囊变、强化情况、浆膜层、周围组织(腹 膜脂肪间隙、邻近脏器)的浸润情况、病 灶区域淋巴结、腹膜种植、远处转移灶; 总结其CT表现,并与病理检查结果对照。 结果 36例GI-NEN的平均直径为45mm,15 例发生于胃,4例发生于十二指肠,17例 发生于直肠。22例呈浸润性生长,14例局 部形成肿块突向管腔(/腔外);10例形成 溃疡,14例出现囊变、坏死;29例呈明显 强化,12例出现分层强化;21例出现浆膜 层侵犯,13例侵犯周围结构,13例邻近淋 巴结肿大,腹膜种植3例,远处转移8例。 结论 胃肠道神经内分泌肿瘤增强扫描明 显强化、沿粘膜下层浸润生长、分层强化 具有一定特征性,CT检查对胃肠道神经内 分泌肿瘤诊断具有重要临床意义。

Objective To summarize the CT findings of gastrointestinal neuroendocrine neoplasm (GI-NEN), so as to improve its diagnostic accuracy. Methods The CT findings of 36 cases of GI-NEN confirmed by pathology were analyzed retrospectively. The following features such as tumor location, size, growth pattern, boundary, thickness of infiltrative lesions, ulceration, cystic change or necrosis, enhancement character, invasion of serous membrane and adjacent organ, lymphadenopathy, peritoneal seeding, distant organ metastasis were reviewed, and were compared with their pathological changes. Results The average diameter of 36 cases of GI-NEN is 45mm. 15 cases located in stomach, 4 cases located in duodenum, 17 cases locatedin rectum. 2 cases were infiltrative growth, 14 cases were circumscribed growth, 10 cases occured ulceration, 14 caes showed cystic change or necrosis, 29 cases showed marked enhancement, layering enhancement appeared in 12 cases, 21 cases invasion into serous membrane, sadjacent organs invasion occured in 13 cases, regional lymphadenopathy occued in 13 cases,3 cases showed peritoneal seeding, 8 cases occurred distant organ metastasis. Conclusion GI-NEN has some characteristic features on CT, CT plays an important role in diagnosis for GI-NEN.

【关键词】神经内分泌肿瘤;胃肠道;体 层摄影术;X线计算机

【中图分类号】R472.9+1

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2017.05.039

前言

神经内分泌肿瘤(neuroendocrine neoplasm,NEN)起源于神经 内分泌细胞,临床少见,近年来,其发病率有增高趋势[1]。胃肠道为 其好发部位,功能性GI-NEN可出现类癌综合征,但大部分的肿瘤为 非功能性[2];约74.7%的胃肠道神经内分泌肿瘤(gastrointestinal neuroendocrine neoplasm,GI-NEN)表现为非特异的消化道症状[3]。 因此,GI-NEN常误诊为其他疾病。GI-NEN的治疗手段,包括(根治/局 部/姑息)手术、化疗、靶向药物、生长抑素类似物还有核素治疗[4]。 但采取何种治疗手段受GI-NEN的发生部位、大小、侵犯层次、转移与 否和病理分级情况等因素影响。CT检查在术前诊断及分期中发挥重要 作用;然而,目前关于GI-NEN的CT研究报道不多,本研究回顾性分析 36例经手术病理证实的GI-NEN的CT、临床及病理资料;分析总结其CT 特征,以期提高对该病的CT诊断水平。