目的 本文旨在研究正常年轻人 性别对其空间导航能力的影响及其与海 马亚区体积的联系。方法 招募63名正常 年轻志愿者进行空间导航测试及头颅磁共 振检查，并通过FreeSurfer软件分割及计 算海马亚区体积。全部受试者按照性别 分为两组。将有差异的空间导航能力值 与海马亚区体积做偏相关分析。结果 正 常年轻人中男性的综合空间导航能力较 女性的差(P=0.047)，这种差异与由于右 侧海马前下托(r=0.313,P=0.013)和下托 (r=0.262,P=0.040)的体积较小有关。结 论 在健康年轻人中，男女的综合空间导 航能力有差异，这可能是由于右侧海马前 下托与下托的体积差异引起的，这一研究 强调了空间导航能力与海马亚区之间的关 系，为下一步更细致地揭示空间导航差异 的结构与功能基础打下了良好的基础。

Objective It is intended to study the impact of normal young people's gender on their spatial navigation capabilities, and its relationship with the volume of the hippocampal subfields. Methods Sixty-three normal young volunteers were recruited to subject spatial navigation test and head magnetic resonance examination. The volume of the bilateral hippocampal subfields was obtained by FreeSurfer software. All subjects were divided into two groups by gender. Using partial correlation analysis to get the relationship between the spatial navigation ability and the hippocampal subfields' volume. Results The mixed spatial navigation ability of men in normal young healthy people was lower than that of women. The difference was found to be related to the smaller size of the right presubiculum and subiculum. Conclusion In healthy young people, there is a difference in the mixed spatial navigation ability between men and women, which due to the difference in the volume of the right presubiculum and subiculum. This study emphasizes the relationship between spatial navigation and hippocampus, lays a structural foundation for further understanding the spatial navigation processing capability.