目的 评价IVIM和DCE-MRI的参 数与非小细胞肺癌(NSCLC)免疫组化指标 MVD、EGFR和Ki67的相关性。方法 选择 2013年4月至2015年2月入住我院的26例经 手术病理证实为非小细胞肺癌的患者， 同时接受IVIM和3D DCE-VIBE序列检查， 分别得到IVIM的水分子扩散效应相关参 数ADCtotal、D值和灌注相关参数D*、f 值，DCE-MRI的灌注参数Ktrans、Kep、Ve和 IAUC60。使用Spearman等级相关系数计算 MRI各参数与免疫组化指标MVD、EGFR和 Ki67之间的相关性。结果 26例NSCLC患者 的MVD均值为(36.5±21.1)，EGFR阳性率 为54.3%，Ki67指标的阳性率为86.4%。 DCE参数中的IAUC60与MVD有中等度的相 关性，r值为0.687，P=0.000<0.05； K trans与MVD有弱相关，r值为0.444， P=0.005<0.05。DCE参数与EGFR和Ki67无 显著相关性。IVIM参数与三种免疫组化 指标均无显著相关性。结论 1)DCE-MRI 可评价NSCLC微循环状态；2)尚不能通过 IVIM和DCE-MRI术前扫描提示NSCLC相关的 EGFR、Ki67免疫组化结果。

Objective To evaluate the correlation between IVIM and DCE-MRI parameters and immunohistochemical indices MVD, EGFR and Ki67. Methods From April 2013 to February 2015, 26 patients (13 males, 13 females; mean age 58 years, range 32-74 years) with pathologically confirmed non-small cell lung cancer were recruited. All patients underwent MR imaging. Axial single-shot respiratory triggered IVIM and breath holding 3D DCE-VIBE sequences were performed. Parameters of IVIM included ADCtotal and D value which reflected water molecule diffusion, and perfusion-related parameters D* and f values. Perfusion parameters of DCE-MRI were Ktrans, Kep, Ve and IAUC60. Spearman rank correlation coefficient was used to calculate the relationship between parameters from IVIM and DCE-MRI and immunohistochemical indices of MVD, EGFR and Ki67. Results Mean MVD of the 26 NSCLCs was (36.5±21.1), positive rate of EGFR was 54.3%, and the positive rate of Ki67 index was 86.4%. Moderate correlation was found between IAUC60 and MVD with r value of 0.687(P=0.000 <0.05), and weak correlation was found between Ktrans and MVD wtih r value of 0.444(P=0.005<0.05). No significant correlation between DCE parameters and EGFR or Ki67 was found. No significant correlation between IVIM parameters and all three immunohistochemical indices was found. Conclusion 1) DCE-MRI, as a non-invasive method, can be used to evaluate the microcirculation of lung cancer, 2) DCE-MRI and IVIM may not be applied to predict the results of EGFR and Ki67 of NSCLC.