目的 分析经皮椎体成形术中应 用冰冻生理盐水对骨水泥渗漏的预防效 果。方法 以我院2011年1月-2012年12月 拟行经皮椎体成形术80例骨质疏松性压缩 性骨折患者为研究对象，依据随机对照原 则将患者分为对照组与观察组各40例，观 察组术中应用冰冻生理盐水干预，对照 组则常规干预(不应用冰冻生理盐水)，术 前、术后均行CT检查，比较2组手术前后 疼痛评分(VAS)及骨水泥渗漏发生率。结 果 观察组与对照组术后3d VAS评分分别 为(2.2±1.0)分、(2.3±1.2)分，较术前 均明显下降(P＜0.05)；但2组组间比较无 显著差异(P＞0.05)。术后CT复查显示观 察组骨水泥渗漏发生率10.0%，显著低于 对照组的30.0%(P＜0.05)。术后1周CT复 查显示观察组与对照组Cobb’角、椎体压 缩率比较差异无统计学意义(P＞0.05)。 结论 CT评价经皮椎体成形术治疗骨质疏 松性压缩性骨折疗效明确，术中应用冰冻 生理盐水能显著降低骨水泥渗漏发生率。

Objective To analyze the effects of the application of frozen normal saline in preventing bone cement leakage in percutaneous vertebroplasty. Methods 80 patients with osteoporotic vertebral compression fractures who were going to undergo percutaneous vertebroplasty in our hospital between January 2011 and December 2012 were included in the study. According to the principle of random control, the patients were divided into the control group and the observation group with 40 cases in each group. The observation group were given frozen normal saline intervention during operation while the control group were given routine intervention (without application of frozen normal saline). CT examination was performed before and after operation. The pain scores (VAS) before and after operation and the incidence of bone cement leakage in the 2 groups were compared. Results On the 3rd day after operation, VAS scores of the observation group and the control group were (2.2±1.0) and (2.3±1.2), respectively which were significantly lower than those before operation (P<0.05). There was no significant difference between the 2 groups (P>0.05). The postoperative CT review showed that the incidence rate of bone cement leakage in the observation group (10.0%) was significantly lower than that in the control group (30.0%) (P<0.05). 1 week after operation, CT review showed that the differences in Cobb'angle and vertebral compression rate between the observation group and the control group were not statistically significant (P>0.05). Conclusion CT is effective in the evaluating the curative effect of percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures. The application of frozen normal saline can significantly reduce the incidence of bone cement leakage.