论著-头颈部
46例垂体瘤的临床 特征及影像特点分 析
作者:岳 欣1 全会标2
所属单位:1.北京和睦家医院内分泌科 (北京 100015) 2.海南省人民医院内分泌科 (海南 海口 570311)
PDF摘要
目的 回顾性总结46例垂体瘤的 临床特征及影像特点。方法 收集我院 2013年2月至2016年2月期间收治的46例垂 体瘤患者作为研究对象展开回顾性分析, 总结垂体瘤在发病年龄、性别、临床表 现、肿瘤类型、大小与形态等方面的特 点。并对垂体瘤的CT及MRI影像表现进行 分析,总结微腺瘤及大腺瘤的CT平扫、 增强扫描及MRI平扫与增强扫描特点。结 果 垂体瘤患者以女性居多,且女性患者 发病年龄明显小于男性患者。临床表现以 头晕、呕吐、视力模糊或下降、溢乳、闭 经、月经紊乱等为主,微腺瘤多无症状。 垂体瘤各类型中以催乳素瘤、混合瘤、 ACTH腺瘤较为常见。微腺瘤平扫检出难度 大,多呈等密度或低密度病灶,增强早期 垂体腺中呈局限性低密度区,边界清晰; 大腺瘤CT平扫可见鞍上池肿物,包膜完 整、边界清晰,呈均匀等密度或稍高密度 区。微腺瘤与大腺瘤的平扫TIWI呈等或略 低信号,T2WI呈高或等信号;增强扫描呈 局限性低密度区,边界清晰。结论 垂体 瘤具有一定临床特点,多发于女性育龄 期,以大腺瘤较多见,患者多可见头晕、 呕吐、视力模糊或下降、溢乳、闭经、月 经紊乱等症状。垂体瘤的CT及MRI影像学 表现有一定特征,对坏死、囊变、出血的 显示良好,作为垂体瘤临床检查手段具有 较大可行性。
Objective To retrospectively summarize the clinical features and imaging characteristics of 46 cases with pituitary adenomas. Methods Forty-six cases with pituitary adenomas treated in our hospital between February 2013 and February 2016 were retrospectively analyzed. The age of onset, gender, clinical manifestations, type, size and shape of pituitary adenomas were summarized. The CT and MRI imaging manifestations of pituitary adenomas were analyzed, and the characteristics of CT plain scan, enhanced scan, MRI scan and enhanced scan were summarized. Results Most of the patients with pituitary adenoma were female, and the age of onset was significantly smaller than that of the male patients. The main clinical manifestations included dizziness, vomiting, blurred or declined vision, galactorrhea, amenorrhea and menstrual disorders. In various types of pituitary adenomas, prolactinoma, mixed tumor and ACTH adenomas were common. The detection of micro-adenoma is difficult, and most of them were equal density or low density lesions. Enhanced early pituitary gland showed a limited low density area, with clear boundary; CT plain scanning of large adenomas showed supra sella cistern hemorrhage, with complete capsule and clear boundary, showing homogeneous density or slightly higher density region. The TIWI of micro-adenomas and large adenomas showed low signal or slightly low signal, and T2WI showed high or equal signal; Enhanced scan showed limited low density region, with clear boundary. Conclusion Pituitary adenomas have certain clinical features and they easily occur in women of reproductive age. Most of them are macroadenomas. Patients have dizziness, vomiting, blurred or declined vision, galactorrhea, amenorrhea, menstrual disorders and other symptoms. CT and MRI imaging manifestations of pituitary adenomas have certain characteristics, which can well display necrosis, cystic change and hemorrhage. Both of the two methods are feasible for clinical examination of adenomas.
【关键词】垂体瘤;临床特征;CT;MRI
【中图分类号】R736.4
【文献标识码】A
【DOI】10.3969/j.issn.1672- 5131.2016.08.027
前言
垂体瘤为内分泌系统常见肿瘤,以颅内最为常见[1],在颅内肿 瘤中所占比例约为5%~20%。2004年世界卫生组织将垂体腺瘤分为七 类:催乳素瘤、生长激素腺瘤、ACTH腺瘤、无功能腺瘤、促性腺激 素腺瘤、促甲状腺激素腺瘤及多激素性腺瘤。根据肿瘤大小将垂体瘤 分为微腺瘤(直径<10mm)、大腺瘤(直径10~40mm)、巨腺瘤(直径> 40mm);从分子生物学角度将其分为垂体良性肿瘤、侵袭性垂体瘤及垂 体癌。垂体瘤多为良性,仅不到0.2%为恶性[2]。随着近年来影像学、 内分泌检查的普及及对疾病认知的不断提高,垂体瘤检出率逐渐升 高,尤其好发于育龄期女性[3]。目前,CT与MRI均为垂体瘤常用检查方 法,但相关研究报道较为缺乏。本研究以我院2013年2月至2016年2月 期间收治的46例垂体瘤患者作为研究对象展开回顾性分析,总结46例 垂体瘤的临床特征及影像特点,以期为垂体瘤的临床诊断提供参考, 现报道如下。
中国CT和MRI杂志
第14卷, 第 8 期
2016年08月
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