目的 研究DWI对儿童急性淋巴细 胞性白血病颅骨骨髓变化的评估及价值。 方法 30例正常对照组及51例患儿组颅骨 骨髓进行MRI检查，行FSE序列T1WI、T2WI 和DWI成像，并测量ADC值。结果 急性淋 巴细胞性白血病患儿组较正常对照组颅骨 ADC值减小，患儿组DWI信号增高组较DWI 信号正常组ADC值亦减小；DWI序列发现急 性淋巴细胞性白血病颅骨浸润较T1WI、 T2WI序列更敏感。结论 DWI及ADC值在诊 断儿童急性淋巴细胞性白血病骨髓浸润有 较高价值。

Objective To assess the role of diffusion weighted imaging(DWI) of Acute lymphoblastic leukemic(All) skull marrow in children. Methods 30 volunteers and 51 Acute lymphoblastic leukemic children underwent MRI with T1weighted imaging(T1WI),T2weighted imaging(T2WI),and DWI ,the values of ADC was obtained. Results the values of ADC in children with All were decreased,as compared with normal volunteers , the values of ADC in All children with high signals of DWI were decreased,as compared with normal signals, the sequence of DWI is better than the sequences of T1WI and T2WI to find the infiltrating areas of skull in All children. Conclusion DWI and the values of ADC have significant value to diagnose the leukemia in chlidren.