目的 探讨计算机断层摄片术 (Computed Tomography，CT)与超声造影 (Contrast-enhanced Ultrasound，CEUS) 定量分析在结直肠癌肝转移早期疗效评估 中的应用价值。方法 将我院2013年2月至 2015年10月收治的45例结直肠癌肝转移患 者按照化疗效果分为有效组19例和无效 组26例，比较2组患者超声检查、CEUS定 量分析及CT增强检查结果。结果 有效组 化疗后CT增强图像和CEUS图像均显示肿 瘤数目明显减少或体积明显缩小；无效 组化疗后CT增强图像和CEUS图像显示稳 定(stable disease，SD)者肿瘤数目和 体积无明显变化，而进展(progression disease，PD)者肿瘤数目明显增多或体积 明显增大。有效组T1时刻上升时间(rise time，RT)明显高于无效组，差异有统 计学意义(P＜0.05)；2组患者其余时刻 RT、平均渡越时间(mean transit time， mTT)、峰值强度(peak enhancement， PE)、流入相曲线下面积(wash-in area under curve，WiAUC)、流入相比率 (wash-in rate，WiR)和流入相灌注指数 (wash-in perfusion index，WiPI)对 比，差异无统计学意义(P＞0.05)。结论 CEUS定量分析实时动态性好，CEUS图像和 时间-强度曲线中的RT值可用于评估结直 肠癌肝转移的早期疗效。

Objective To explore the values of early curative effect evaluation for the patients with hepatic matastasis of colorectal cancer by CT and Contrast-enhanced Ultrasound quantitative analysis. Methods 45 cases of patients with hepatic matastasis of colorectal cancer were divided into effective group(19 cases) and ineffiecacy group(26 cases), the ultrasound, CEUS quantitative analysis, enhancement CT were compared. Results The CT enhanced imaging and CEUS imaging for the effective group showed that tumor number decreased significantly or significantly smaller. The CT enhanced imaging and CEUS imaging for the ineffiecacy group showed that stable disease number of tumor, volume no change, the PD showed that number of tumor bigger or volume are increased. The rise time T1 for the effective group were higher than ineffiecacy group(P ＜0.05). There had no significant difference on the RT, mTT, PE, WiAUC, WiR, WiPI(P＞0.05). Conclusion It has good realtime and dynamic for Contrast-enhanced Ultrasound quantitative analysis, the RT values of CEUS can evaluation for the patients with hepatic matastasis of colorectal cancer.