目的 探讨颅骨修补术前后脑组 织的血流灌注变化。方法 选取30例在我 院行颅骨修补术的患者作为研究对象， 在术前2d、术后10d，分别对患者行CT脑 灌注成像检查，观察、分析本组患者手 术前后的脑组织血流灌注相关指标的变 化。结果 本组患者患侧术前大脑皮层的 CBV、CBF值均显著低于健侧，MTT、TTP 值均显著高于健侧，(P<0.05)；术后， 患侧大脑皮层的CBV、CBF值较术前均有 明显提高，MTT、TTP值较术前明显降低 (P<0.05)。患侧术后大脑皮层的CVB、 CB、MTT、TTP值与健侧比较无明显差异 (P>0.05)。本组患者术前的FIM评分平均 值为(111.64±12.06)分，术后的FIM平均 值为(120.87±8.54)分，二者比较，差异 有统计学意义(P<0.04)。结论 颅骨修补 术能够有效增加患侧大脑皮质区的血流灌 注，促进神经功能恢复，CT脑灌注成像是 监测脑组织血流灌注变化的有效手段。

Objective To study the skull to repair the blood perfusion of preoperative afterbrain organization change. Methods Selecting 30 cases in our hospital patients with bone repair as the research object, in 2 d, 10 d after operation, preoperative respectively for patients with CT cerebral perfusion imaging, observation and analysis of this group of patients before and after surgery related index of tissue perfusion changes. Results The patients with lateral CBV, CBF value of preoperative cerebral cortex were significantly lower than the healthy side, determined by MTT, TTP values were significantly higher than that of the healthy side, P<0.05. After surgery, CBV, CBF value of lateral cerebral cortex are obviously improved, compared with preoperative determined by MTT, TTP values compared with preoperative significantly decreased (P<0.05). One side of the cerebral cortex after CVB, CB, determined by MTT, TTP values compared with the contralateral has no obvious difference (P>0.05). For this group of patients with preoperative FIM score average (111.64±12.06), the average postoperative FIM is (120.87 ±8.54) points, the comparison, the difference was statistically significant (P<0.04). Conclusions The repair of skull can effectively increase the blood perfusion of lateral cortical area, promote the nerve functional recovery, CT cerebral perfusion imaging is an effective method for monitoring the change of tissue perfusion.