目的 通过磁共振LAVA动态增强 (DCE-MRI)相关参数的分析，探讨DCE-MRI 对前列腺癌的诊断价值。方法 对经组织 病理学证实的29例PCa和58例BPH患者行肝 脏快速容积采集序列(LAVA)多期动态增强 扫描，获得SI-T曲线，并计算出峰值时 间(Tmax)、最大信号强度(Slmax%)、强化 率(R)、流出分数(washout)，比较各参 数在PCa、gBPH、sBPH之间的差异，并进 行ROC曲线分析。结果 PCa组SI-T曲线以 速升下降型为主，gBPH、sBPH组以平台型 为主；Tmax、R、Washout三组组间差异有 统计学意义(P<0.05)，Slmax%组间差异无 统计学意义(P>0.05)；Tmax、R、Washout 值gBPH与sBPH分组间差异无统计学意义 (P>0.05)；Tmax的ROC曲线下面积最大，诊 断敏感度及特异度分别为93.6%、84.6%； PCa组Tmax多在1分钟内(75.9%)，sBPH组Tmax 多在1-2分钟内(55.5%)，而gBPH组Tmax多 在两组区间，即1-2分钟(42.5%)及2分钟 后(40.0%)。结论 DCE-MRI半定量分析在 前列腺癌诊断中具有较高价值，可用于前 列腺良恶性病变的鉴别诊断。

Objective By analyzing the LAVA dynamic enhanced magnetic resonance (DCE-MRI) related parameters to evaluate the diagnostic value of DCE-MRI for prostate cancer. Methods 29 patients with PCa and 58 BPH patients with liver histopathology confirmed the line fast volume acquisition sequence (LAVA) multiphase dynamic enhanced scan, access SI-T curve, and calculate the peak time (Tmax), the maximum signal strength (Slmax %), enhancement ratio (R), out of scores (washout), compare the differences in the parameters between PCa, gBPH, sBPH of, and ROC curve analysis. Results PCa group SI-T curve at a speed drop liter main type, gBPH, sBPH platform-type-based group; between Tmax, R, Washout three groups was statistically significant (P<0.05) differences between the groups was not Slmax% statistically significant (P>0.05); Tmax, R, Washout value between gBPH and sBPH group showed no significant difference (P>0.05); area under the ROC curve Tmax largest diagnostic sensitivity and specificity were 93.6%, 84.6%; PCa group within Tmax more (75.9%) one minute, sBPH group more in Tmax (55.5%) for 1-2 minutes, and two more in gBPH group Tmax range, ie 1-2 minutes (42.5%) and after 2 minutes (40.0%). Conclusion Semi-quantitative analysis of DCE-MRI has a higher value in the diagnosis of prostate cancer can be used for differential diagnosis of benign and malignant prostate lesions