论著-头颈部
肝硬化门静脉高压侧支血管开放的影像学特征及临床意义*
作者:张嘉瑜1 刘龙平2 王成林2
所属单位:1.汕头大学医学院(广东 汕头 515041) 2.北京大学深圳医院(广东 深圳 518036)
PDF摘要
目的 探讨肝硬化引起的门静脉 高压侧枝血管开放的影像学特征及临床意 义。方法 收集从2013年2月至2015年9月 于我院住院的肝硬化病人92例,包括病人 肝性脑病、腹水的临床资料及白蛋白、凝 血酶原时间等实验室指标,并进行肝功能 Child分级;所有患者均行CT门静脉成像 检查,并在工作站进行最大密度投影等 图像后处理,分析各侧枝循环之间的相 互关系及侧支循环与肝功能Child分级、 临床表现、实验室检查之间的关系。结 果 CT门静脉成像可以清楚显示各侧枝循 环的起止、走行及形态特点;食管静脉、 食管旁静脉、附脐静脉三者随肝功能严重 程度增高出现率上升(P<0.05);胃左静 脉宽度的增大可以导致更多侧枝血管开放 (P<0.05);食管旁静脉可以降低食管静 脉曲张但不能减少胃底静脉曲张;食管静 脉、食管旁静脉、胃底静脉、附脐静脉的 曲张可提高腹水的发生率(P<0.05);不 同侧枝血管开放支数的实验室指标如白蛋 白、凝血酶原时间等差别不具有统计学意 义(P>0.05)。结论 CT门静脉成像对于观 察各种侧枝循环的起止、走行及形态特点 具有巨大优势,可以为临床诊治评估提供 客观依据,了解不同侧枝循环相互间关系 及其与临床表现的关系对病情评估和预后 判断具有重要价值。
Objective To explore the clinical significance and imaging features of collateral vessels in the portal hypertension of hepatic cirrhosis. Methods 92 hospitalized cases of hepatic cirrhosis from February, 2013 to September, 2015 were collected, including the clinical data of hepatic encephalopathy, ascites and albumin, prothrombin time, etc. All the cases were classified into three groups according to Child-Pugh classification standard and they were all examined CT portal venography. All the images were given image postprocessing such like VR (Volume Rendering), MIP(Maximun Intensity Projection), et al. The data of different collateral vessels were used to analyzed the relationship of themselves and their connection with the clinical manifestations and laboratory tests. Results CT portal venography can show the beginning and end, route and forms of different collateral varices clearly. The occurance rate of esophageal vein, Paraesophageal vessels, paraumbilical vein increased by the worse liver function(P<0.05). The width enlargement of left gastric vein lead to more collateral varices(P<0.05); Paraesophageal vessels can reduce the occurance of esophageal varices(P<0.05) rather than gastric varices(P>0.05); The occurance rate of ascites increased while there were esophageal, Paraesophageal, gastric or paraumbilical varices(P<0.05). The difference between the laboratory tests such as albumin, prothrombin time, total bilirubin and the amount of collateral vessels was not statistically significant(P>0.05). Conclusion CT portal venography is a dominant technique to show the beginning and end, route and forms of different collateral circulation which can provide objective base to clinical diagnosis and treatment. It is important to understand the relationship between each other and their relationship with clinical manifestation for the disease assessment and prognostic judgement.
【关键词】肝硬化;门静脉高压;侧支循环;CT门静脉成像
【中图分类号】R445.3;R757.2
【文献标识码】A
【DOI】10.3969/j.issn.1672- 5131.2016.01.024
前言
病毒性肝炎是引起肝硬化是常见的原因,肝硬化不仅使罹患肝癌 的风险增高,它还可引发门脉高压从而导致消化道出血、肝性脑病、 腹水等并发症。而门静脉高压引起的侧枝血管开放在疾病的发生、进 展中具有重要的作用。正确评价侧枝血管开放情况,对患者的治疗和 预后均有重要意义。近年来,CT门静脉成像被认为是评价门静脉高压 侧支循环的最佳检查手段。本文对92例肝硬化门脉高压患者的侧支血 管开放状态进行观察,评价其临床应用价值,并研究侧枝循环之间的 相互关系及其与临床表现、实验室指标的关系。
中国CT和MRI杂志
第14卷, 第 1 期
2016年01月
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