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64层螺旋CT对心肌梗塞患者的价值分析*

作者:龚中明 江志荣 徐峻峰

所属单位:湖北省鄂州市莲花山医院心内科(湖北 鄂州 436000)

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摘要

目的探讨低剂量平扫64层螺旋 CT评价心肌梗塞患者的心外膜脂肪组织价 值。方法 2011年7月到2014年8月选择在 我院诊治的心肌梗塞患者90例,都使用低 剂量平扫64层螺旋CT判定阻塞性粥样硬化 情况,同时进行心外膜脂肪厚度的测定 与临床一般资料的记录。结果 90例心肌 梗塞患者判断为无阻塞粥样硬化60例,阻 塞性粥样硬化30例,两组的性别、年龄、 体重指数、TG、TC、LDL、HDL与空腹血糖 值对比差异都无统计学意义(P>0.05)。无 阻塞粥样硬化患者的心外膜脂肪厚度为 5.67±1.23mm,而阻塞性粥样硬化患者为 9.24±1.46mm,阻塞性粥样硬化患者的心 外膜脂肪厚度明显高于无阻塞粥样硬化患 者(P<0.05)。Logistic回归分析显示心外 膜脂肪厚度是导致阻塞粥样硬化的独立危 险因素,呈正相关(P<0.05)。Pearson相 关分析结果显示心外膜脂肪厚度与年龄、 空腹血糖、TG呈正相关;与HDL-C呈负相 关(P<0.05)。结论 低剂量平扫64层螺旋 CT评价能有效评价心肌梗塞患者的心外膜 脂肪组织厚度与阻塞粥样硬化情况,心外 膜脂肪组织是心肌梗塞阻塞粥样硬化的一 个重要危险因素,同时也受临床许多因素 影响。

Objective To investigate the values of Low-dose unenhanced 64-slice CT for the epicardial adipose tissue in the myocardial infarction patients. Methods From July 2011 to August 2014 ,90 myocardial infarction patients in our hospital were examined by low-dose unenhanced 64-slice CT to assess obstructive atherosclerosis, while measured epicardial fat thickness general information and kept the clinical records. Results 60 patients of the non-blocking atherosclerosis, 30 patients of obstructive atherosclerotic were finally confirmed in 90 patients with myocardial infarction, the gender, age, BMI, TG, TC, LDL, HDL and fasting blood glucose of the two were no differences in contrast statistically significant (P>0.05). Blocking atherosclerosis in patients with epicardial fat thickness were 5.67 ± 1.23mm, while obstructive atherosclerotic patients were 9.24 ± 1.46mm, epicardial fat thickness obstructive atherosclerosis in patients with atherosclerosis was significantly higher than that of non-blocking sclerosis patients (P<0.05). Logistic regression analysis showed that epicardial fat thickness was the independent risk factor for atherosclerosis obstruction and was positively correlated (P<0.05). Pearson correlation analysis showed that epicardial fat thickness and age, fasting blood glucose, TG was positively correlated; and HDL-C was negatively correlated (P<0.05). Conclusion Lowdose unenhanced 64-slice spiral CT evaluation can effectively evaluate the thickness of the myocardial infarction patients with obstructive epicardial adipose tissue atherosclerosis. Epicardial adipose tissue is an important risk factor for obstructive atherosclerosis of myocardial infarction, which is also affected by a number of clinical factors.

【关键词】低剂量平扫64层螺旋CT;心肌梗塞;心外膜脂肪组织;阻塞 粥样硬化

【中图分类号】R445.3;R541.4.

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2015.11.011

前言

心肌梗塞是临床上的常见疾病,虽然当前其在我国的发病率少于 欧美,但是发病率当前呈现增长的趋势[1-2]。脂肪组织分布在全身各 处,研究证明区域性脂肪组织的分布是心血管疾病的重要危险因子, 其中心外膜脂肪可能在心血管疾病的发生发展上起重要作用[3-4]。心外 膜脂肪是沉积在心脏周围的内脏脂肪,其能缓冲冠脉因动脉脉冲和心 脏收缩引起的扭转,调节冠脉微循环中脂肪酸的动态平衡[5]。不过在 定量心外膜脂肪分娩,体重指数(BMI)这种反映全身脂肪含量的测量指 标不是心外膜脂肪的主要决定因素,而腰围(WC)、臀围(HC)等虽然反 映脂肪分布,但是不能很好的预测脂肪的量[6]。螺旋CT评等影像学测 量工具的简单易行,其对于内脏脂肪体积及心外膜脂肪体积测定较可 靠[7]。本文具体探讨了低剂量平扫64层螺旋CT评价心肌梗塞患者的心 外膜脂肪组织价值,现报告如下。