目的应用磁共振弥散张量成像 (diffusion tensor imaging，DTI)研究 并鉴别阿尔茨海默病与轻度认知障碍患者 的脑白质损伤情况。方法 对于45例阿尔 茨海默病患者(AD组)和45例轻度认知障碍 患者(MCI组)进行脑部DTI扫描，测量部分 区域各项异性分数值(FA)和平均弥散率 (mean diffusivity，MD)并进行比较。结 果 与MCI组相比，AD组两侧海马旁回、两 侧下额枕束、两侧下纵束和两侧后扣带回 的FA值均显著降低，P<0.05。与MCI组相 比，AD组两侧海马旁回、两侧下额枕束、 两侧下纵束和两侧后扣带回的MD值均显著 升高，P<0.05。结论 DTI技术可以灵敏 检测出AD患者与MCI患者的脑白质结构差 异，从而可作为MCI与AD的鉴别指标。

Objective to application of magnetic resonance diffusion tensor imaging (coursing together tensor imaging, DTI) research and identification of alzheimer's disease and mild cognitive impairment in patients with cerebral white matter damage. Methods for 45 cases of alzheimer's disease (AD) and 45 cases of patients with mild cognitive impairment (MCI) in brain DTI scan, measure the area of the opposite sex (FA) and an average score value dispersion rate (mean diffusivity, MD) and the comparison. Results compared with MCI group, AD groups on both sides of the parahippocampal gyrus, sides on both sides of the pillow, on both sides of the longitudinal beam and cingulate FA values were significantly lower after, P<0.05). Compared with MCI group, AD groups on both sides of the parahippocampal gyrus, sides on both sides of the pillow, on both sides of the longitudinal beam and the cingulate cortex, MD, of the rise, P<0.05). Conclusions DTI technology can be sensitive to detect the AD patients with MCI patients of cerebral white matter structure difference, which can be used for identification of MCI and AD.