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CT灌注成像在诊断急性脑缺血中的运用和研究*

作者:黄文清 蔡 辉 杨湘伟 翁 义

所属单位:广东省潮州市中心医院放射科(广东 潮州 521021)

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摘要

目的研 究 C T 灌 注 成 像 ( C T perfusion imaging, CTPI)在诊断急性脑 缺血中的运用效果,为急性脑缺血的诊 断提供有效依据。方法 运用随机抽样的 方法选取我院放射科2012年1月至2014年 9月收治的80例急性脑缺血患者,运用GE Lightspeed 128层螺旋CT 扫描机对患者 进行检查,然后对CT灌注成像各个参数及 CTPI各个参数图异常灌注区面积相关性进 行统计分析。结果 80例急性缺血性脑卒 中患者中,72例患者CTPI异常,急性脑缺 血诊断的敏感性为90.00%(72/80);CTPI 的CBF、CBV、MTT、TTP、PE异常率均显著 高于单层CPCI(P<0.05);CBF、CBV、MTT 呈线性正相关且具有较好的相关性,差异 具有统计学意义(P<0.05)。结论 CTPI在 诊断急性脑缺血中具有较高的敏感性和异 常率,运用效果良好,值得在临床推广。

Objective To study the application effect of CT perfusion imaging (CTPI) in the diagnosis of acute cerebral ischemia, so that to provide effective basis for the diagnosis of acute cerebral ischemia. Methods 80 cases of patients with acute cerebral ischemia who were treated in Department of our hospital from January 2012 to September 2014 were selected by random sampling method, the patients were checked by the GE Lightspeed 128-slice CT scanner, then the CT perfusion imaging area and the correlation between various parameters and each parameter map CTPI abnormal perfusion were statistically analyzed. Results Among the 80 cases of acute ischemic stroke patients, 72 cases CTPI were abnormal, the sensitivity in the diagnosis of acute cerebral ischemia was 90.00% (72/80); The CBF, CBV, MTT, TTP, PE abnormalities of CTPI were significantly higher than the single-CPCI (P<0.05); CBF, CBV, MTT showed positive linear correlation and had good correlation, the differences were statistically significant (P<0.05). Conclusion The application effect of CTPI is good in the diagnosis of acute cerebral ischemia, it has higher sensitivity and abnormal rate, so is worthy of promotion in the clinical.

【关键词】CT灌注成像;急性脑缺血;诊断;运用;研究

【中图分类号】R743.31

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2015.11.005

前言

1991年Miles等首先提出CT灌注成像的概念[2];国内2004年对脑 缺血CT灌注研究报道,现在技术趋向成熟;但临床运用相对还是较少 [3]。本研究对我院放射科2012年1月至2014年9月收治的80例急性脑缺 血患者的临床资料进行了统计分析,研究了CTPI在诊断急性脑缺血中 的运用效果,现报告如下。