目的探讨全肝MR动态增强扫描 评估肝纤维化的可行性。方法 89例患者 经病理证实存在肝纤维化(S1-S3组)，另 选35例无肝纤维化患者为对照组(S0组)， 所有患者行全肝MR动态增强扫描，绘制 时间-信号强度曲线(TIC)并分析其主要 特征，记录达峰时间(TTP)，信号上升最 大斜率(MSI)，最大强化率(MER)，对比分 析S0-S3组的时间-信号强度曲线特征、 TTP、MSI、MER。结果 S0组及S1-S3组AO 的TIC形态无差异。S1-S3组的PV、LHL及 RHL的峰值相对滞后，波峰宽大，LHL及 RHL曲线形成较长时间平台期，峰值不明 显。不同肝纤维化分期患者中AO的TTP、 MSI组间无统计学差异(P>0.05)，余组 间的TTP、MSI、MER存在统计学差异(P﹤ 0.05)。结论 全肝MR容积动态增强的时 间-信号强度曲线特征及参数可以作为评 估肝纤维化的指标，具有一定的临床应用价值。

Objective To investigate the feasibility of assessing liver fibrosis with volume dynamic contrast enhanced MR imaging of the whole liver. Methods 35 patients with pathologically confirmed the presence of fibrosis, other 89 patients without liver fibrosis patients as the control group. All patients underwent volume dynamic contrast enhanced MR imaging of the whole liver, drawing the time signal intensity curve (TIC) and analyzed its main features, record the time to peak(TTP), maximum slope of increase(MSI) and maximum contrast enhancement ratio(MER). The type of TIC, TTP, MSI, and MER were compared between the case group and control group. Results The types of TIC of AO were no difference between the control group and the case group. The peak time of PV, LHL and RHL of the case group were delayed and had big wave. The type of TIC of LHL and RLH of the case group had platform period．The TTP、MSI、MER of AO, PV, LHL and RHL were significant differences between the S0 to S3 groups(p<0.05), except differences between TTP、MSI of AO(p>0.05). Conclusion The characteristics of TIC from volume dynamic contrast enhanced MR imaging of the whole liver could be used to assessing the liver fibrosis, and had certain diagnostic value.