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胸部多排螺旋CT联合超声内镜检查在胸段食管癌术前分期中的应用*

作者:李学农 张文清 胡宴宾 陈仲平 和建冰 李刚毅

所属单位:深圳市龙华新区中心医院/广东医学院附属观澜医院医学影像科(广东 深圳 518110)

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摘要

目的探究胸部多排螺旋CT联合 超声内镜检查在胸段食管癌术前分期的准 确性。方法 选取我院90例食管癌患者, 患者术前均进行超声内镜检查、胸部多排 螺旋检查,并对食管癌进行分期,术后患 者肿瘤组织病理学分期为诊断的金标准, 比较单用超声内镜、单用胸部多排螺旋及 二者联合应用三种检查方法T与N分期的准 确性。结果 二者联合应用在T1、T2分期 准确性高于MDCT,但与EUS差异小,T3、 T4分期准确性及总准确性要高于单用EUS 及单用MDCT;二者联合应用在N分期上敏 感性、特异性,准确性及ROC曲线面积均 高于单用EUS、单用MDCT,单用EUS敏感 性为68.5%、特异性为70.6%、准确性为 68.9%,ROC曲线面积为0.901;单用MDCT 敏感性为63.0%、特异性为64.7%、准确性 为63.3%,ROC曲线面积为0.853;二者联 合应用敏感性86.3%、特异性82.4%、准确 性为85.6%,ROC曲线面积为0.952。结论 胸部多排螺旋CT联合超声内镜检查可以显 著提高胸段食管癌术前T、N分期的准确 性。

Objective To assess the combined application of endoscopic ultrasound and multi-detector row spiral CT in preoperative staging of esophageal cancer. Methods Choose 90 esophageal carcinoma patients who had been checked with endoscopic ultrasound and multi-detector row spiral CT. and do staging of esophageal cancer. Choose the pathological staging of the patient postoperative tumor tissue as the gold standard. Compare the T and N stages of the single use of endoscopic ultrasound and multi-detector row spiral CT, the combination of the two application. Results The combined application in T1, T2 staging accuracy is higher than MDCT, but the difference compared with EUS is less, The combined application in T3, T4 staging accuracy and total accuracy is higher than the single use of EUS and MDCT; The combined application in the N staging of sensitivity, specificity, accuracy and the area under ROC curve were higher than single use of EUS, MDCT. The sensitivity,specificity , accuracy and the area under ROC curve of the single use of endoscopic ultrasound and multi-detector row spiral CT, the combination of the two applications were 68.5%, 70.6%,80.90%, 0.901; 63.0%, 63.3%, 0.853; 86.3%, 82.4%, 85.6%, 0.952. Conclusion Thoracic multi-detector row spiral CT combined with endoscopic ultrasonography can improve the accuracy of thoracic esophageal carcinoma preoperative T, N staging significantly.

【关键词】胸部多排螺旋CT;食管癌术前分期;超声内镜

【中图分类号】R445.3; R537.1

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2015.04.13

前言

食管癌由于具有早期症状体征不明想、肿瘤与淋巴结有跳跃式转 移特点,临床疗效不理想。对食管癌进行准确分期,有助于制定针对 性治疗方案,使治疗更合理、更准确,在一定程度上提高临床疗效 [1]。目前单用多排螺旋CT、单用超声内镜是食管癌比较普及的检查方 法,通过回顾性分析90例食管癌患者,探究胸部多排螺旋CT联合超声 内镜检查在胸段食管癌术前分期的准确性。