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Effects of Different Doses of Pulmonary Surfactant in the Treatment 86 Neonates with Severe RDS

Author：QI Ya-ping, ZHANG Hui-yong, SONG Yue,et al

affiliation：Department of Neonatology, Luohe Second People's Hospital, Luohe 462000, Henan Province, China

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Abstract

Objective To investigate the effects of different doses of pulmonary surfactant (PS) on severe respiratory distress syndrome (RDS) in neonates. Methods 86 neonates with severe RDS in our hospital were taken as the research objects, and they were randomly divided into the study group and the control group with 43 cases in each group. The study group was given 100mg/kg PS every time, while the control group was given 70mg/kg PS every time. The changes of arterial blood gas indexes [arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2) and oxygenation indexes (OI)] in the two groups were compared before and after treatment, and the complications in the two groups were analyzed. Results 12h after treatment, the PaO2 levels in the two groups were significantly increased, and the increase in the study group was significantly higher than that in the control group (P<0.05). while PaCO2 and OI levels in the two groups were significantly decreased, and the decrease in the study group was significantly lower than that in the control group (P<0.05). 14d after treatment, the incidence rate of complications in the study group was lower than that in the control group (P<0.05) . Conclusion High dose PS which is beneficial to the prognosis of the disease, can achieve better therapeutic effect for neonates with sever RDS.

【Keyword】Pulmonary Surfactant; Neonate; Respiratory Distress Syndrome

【Chart number】R272.1

【Document Identification Number】A

【DOI】10.3969/j.issn.1009-3257.2019.02.021

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