Head and Neck Imaging
Relationship between Serum Levels of Hcy, VEGF and TGF-β1 and Early Diabetic Nephropathy
Author：ZENG Guo-zhi, MENG Guo-huang.
affiliation：Department of Clinical Laboratory, Gaozhou Hospital of Traditional Chinese Medicine, Gaozhou 525200, Guangdong Province, China
PDFAbstract
Objective To analyze the relationship between levels of serum homocysteine (Hcy), vascular endothelial growth factor (VEGF) and serum transforming growth factor-β1 (TGF-β1) and early diabetic nephropathy (DN). Methods 120 patients with type 2 diabetes mellitus (T2DM) admitted to our hospital from January 2015 to January 2017 were selected for the study. According to the urinary albumin excretion rate (UAER) level, they were divided into simple T2DM group (n=61) and early DN group (n=59), and another 120 healthy examiners at the same time period were selected as control group. The levels of serum Hcy, VEGF and TGF-β1 were compared among the three groups, and their relationship with early DN was analyzed. Results The levels of Hcy, VEGF and TGF-β1 were gradually increased in control group, T2DM group and early DN group, and the differences between-groups were significant (P<0.05). Logistic analysis showed that serum Hcy, VEGF and TGF-β1 were all risk factors for early DN. Conclusion Serum levels of Hcy, VEGF and TGF-β1 are effective biochemical markers for early diabetic nephropathy, and they can be used for clinical detection.
【Keyword】Serum Hcy; VEGF; TGF-β1; Early Diabetic Nephropathy; Relationship Analysis
【Chart number】R587.2；R446.11
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2019.02.024
Journal of Rare Diseases
th26Volume， th 2 Issue
2019Year03Month
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