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Effects and Prognosis of Narrow-band Ultraviolet Wave Combined with Compound Kaliziran Tincture in the Treatment of 150 Cases of Vitiligo

Author：ZHAO Lei.

affiliation：Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China

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Abstract

Objective To explore the effecst of narrow-band ultraviolet (NB-UVB) combined with compound Kaliziran tincture (KT) in the treatment of vitiligo. Methods A total of 150 patients with vitiligo were selected as subjects and were divided into combined group (n=75) and control group (n=75) according to the random number table method. Combined group was given NB-UVB irradiation combined with external application of KT, and control group was only treated with NB-UVB. The changes of serum interleukin-17 (IL-17) level, skin lesion area and self-esteem [Rosenberg SelfEsteem Scale (RSES)] were compared between the two groups before and after 3 months of treatment. The treatment effects and occurrence of adverse reactions during treatment were analyzed in the two groups. Results After 3 months of treatment, the serum IL-17 level, skin lesion area and RSES score in the two groups were significantly improved compared with those before treatment, and the improvements were better in combined group (all P<0.05). The treatment effects in combined group were significantly better than those in control group (P<0.05), and there was no statistically significant difference in the incidence rate of adverse reactions between the groups (all P>0.05). Conclusion NB-UVB combined with KT regimen can be safely and effectively applied to vitiligo treatment.

【Keyword】Narrow-band; Ultraviolet; Compound Kaliziran Tincture; Vitiligo

【Chart number】R758.4+1

【Document Identification Number】A

【DOI】10.3969/j.issn.1009-3257.2019.02.030

Journal of Rare Diseases

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