Objective To explore the effects of comfortable posture nursing on nursing satisfaction, comfort and postoperative complications in patients undergoing transurethral vaporization of prostate. Methods 98 patients who underwent transurethral vaporization of prostate in our hospital from February 2017 to February 2018 were selected as subjects and were divided into observation group and control group according to the random number table method, with 49 cases in each group. Control group was given routine nursing, and observation group was additionally given comfortable posture nursing on this basis. The patients were given visit by visiting nurse on the 2nd d after operation, and the patients’ satisfaction with operating room nursing and the postoperative comfort (VAS) were evaluated, and the occurrence of postoperative complications (postoperative infection, postoperative bleeding, urinary incontinence) was counted by assistance of ward nurse before discharge. Results On the 2nd d after operation, the nursing satisfaction and VAS scores in observation group showed that the proportion of patients with no discomfort was significantly higher than that of control group (all P<0.05). Before discharge, the total incidence rate of postoperative complications in observation group was significantly lower than that in control group (P<0.05). Conclusion Comfortable posture nursing can improve the nursing satisfaction and comfort of patients with transurethral vaporization of prostate, and it can effectively reduce the incidence rate of postoperative complications.