Objective To observe the therapeutic effect of laser photocoagulation combined with intravitreal injection of conbercept on diabetic macular edema (DME) and its influence on prognosis. Methods The clinical data of 97 DME patients (97 eyes) treated in our hospital from January 2016 to January 2017 were retrospectively analyzed. All the patients were divided into conbercept plus laser photocoagulation group (study group, n=54) and laser photocoagulation group (control group, n=43) according to their treatment plans. The treatment conditions [best corrected visual acuity (BCVA) and central macular thickness (CMT)] were detected before treatment (T1) and 1, 2, 3 months (T2, T3, T4) after treatment, and the adverse reactions in the two groups were also observed. Results From T1 to T4, the differences in the intergroup effect, time point effect and interaction effect were statistically significant(P<0.05), the BCVA levels in the two groups were increased over time, and the BCVA levels in the study group were all higher than those in the control group from T2 to T4 (P <0.05), the CMT levels in the two groups were decreased over time, and the CMT levels in the study group were all less than those in the control group from T2 to T4 (P<0.05); there was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion Intravitreal injection of conbercept combined with laser photocoagulation which is safe and effective, can effectively improve the visual acuity and macular edema symptoms in DME patients, and it is also beneficial to the recovery of the patients' disease.