Head and Neck Imaging
Effect of Sulodexide on Serum VEGF, ACE and IGF-1 Levels in Patients with Diabetic Nephropathy and Retinopathy
Author：ZHAO Jun-hua, ZHOU Zhi-jie, CUI Ji-gang,et al
affiliation：Department of Respiratory Nephrology, Luoyang Oriental Hospital, Luoyang 471003, Henan Province, China
PDFAbstract
Objective To explore the effect of sulodexide on serumvascular endothelial growth factor (VEGF), angiotensin converting enzyme (ACE) and insulin-like growth factor -1 (IGF-1)levels in patients with diabetic nephropathy (DN) and diabetic retinopathy (DR). Methods 72 patients with DN and DR were randomly divided into study group (36 cases) and control group (36 cases). The control was given alprostadil, irbesartan and European bilberry anthocyanin / beta carotene, while the study group was given sequential therapy with sulodexide. The curative effects of DR in the two groups were compared, and the changes of urinary albumin excretion rate (UAER), serum VEGF, ACE and IGF-1 levels were observed before and after treatment. Results There was no significant difference in the curative effects of DR between the two groups (P>0.05). 16 weeks after treatment, the levels of UAER, VEGF, ACE and IGF-1 in the two groups were all significantly decreased, and the decrease in the study group was greater than that in the control group (P<0.05). Conclusion Sulodexide can effectively alleviate the fundus lesions in patients with DN and DR, promote the recovery of renal function, and delay the disease progression through reducing the expression of serum VEGF, ACE and IGF-1.
【Keyword】Sulodexide; Diabetic Nephropathy; Retinopathy; VEGF; IGF-1
【Chart number】R587.1
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2019.02.009
Journal of Rare Diseases
th26Volume， th 2 Issue
2019Year03Month
Related articles
Editor email：（1）中国CT和MRI杂志：ctmri@vip.163.com；（2）罕少疾病杂志：hs1999@vip.163.com
Contact number：0755-83695203
Our address：
English
简体中文
logged in
Wechat
TouTiao