Objective To analyze the application value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters combined with diffusion weighted imaging (DWI) in evaluating the curative effect of neoadjuvant chemotherapy for breast cancer. Methods A total of 90 patients with breast cancer confirmed by puncture biopsy in the hospital were selected. All tumors were invasive ductal carcinomas, and they were treated by neoadjuvant chemotherapy (4-6 cycles). The patients were examined by DCE-MRI and DWI before and after chemotherapy, and according to the results of puncture biopsy (the presence of infiltrating again), the patients were divided into chemotherapy remission group (n=52) and ineffective group (n=38). The quantitative parameters of DCE-MRI and DWI apparent diffusion coefficient (ADC) were compared between the 2 groups before and after chemotherapy. Results There were obvious changes of Kep, Ve and Ktrans in the 2 groups before and after chemotherapy (P<0.05), and the change in the remission group was more significant than that in the ineffective group (P<0.05). The ADCmin and ADCmean in the 2 groups increased significantly after chemotherapy (P<0.05), and the increase in the remission group was more significant than that in the ineffective group (P<0.05). The accuracy, specificity, sensitivity and Kappa value of DCE-MRI combined with DWI were 91.11% (82/90), 94.74% (36/38), 88.46% (46/52) and 0.82, respectively. Conclusion DCE-MRI quantitative parameters combined with DWI can evaluate the invasion and metastasis of breast cancer after neoadjuvant chemotherapy, so as to accurately evaluate the curative effect of neoadjuvant chemotherapy for breast cancer.