Objective To investigate the correlation between quantitative evaluation index of coronary angiography (CTA) and myocardial ischemia. Methods A total of 157 patients underwent coronary angiography in the radiology department of our hospital in September 2015-2017 August, the original data were transferred to workstations for plaque analysis of coronary arteries and branches with stenosis exceeding 25%. The postprocessing workstation automatically obtains the objective indexes such as calcification integration, plaque volume, plaque load, stenosis degree and reconstruction index, and compares the difference of CTA quantitative evaluation index in myocardial ischemia and its correlation with myocardial ischemia events. Results The calcification score, plaque load, stenosis degree and reconstruction index of myocardial ischemia group were higher than those without myocardial ischemia group, the difference was statistically significant(P<0.05), and plaque volume was no statistically significant difference in two patients (P>0.05). There was a significant positive correlation between calcium integration, plaque load, stenosis and reconstruction index and myocardial ischemia, which was statistically significant (P<0.05). Conclusion Coronary artery CTA examination can evaluate myocardial ischemic events by objective quantitative indicators, which can be widely used in clinic.