Objective To explore the value of dual-source CT (DSCT) in the diagnosis of coronary artery anomaly. Methods The clinical data of 60 patients with coronary artery anomaly diagnosed by coronary artery DSCT in the hospital from September 2016 to September 2017 were retrospectively analyzed. Among them, 33 patients underwent coronary angiography (CAG). DSCT imaging findings of patients with coronary artery anomalies were analyzed. The diagnostic results were compared between DSCT and CAG. Results The detection rate of coronary artery anomaly was 5.83%. The diagnosis with DSCT of 60 patients with coronary artery anomalies was good. The coronary artery anomalies mainly included right coronary artery fistula, the right coronary artery to the left coronary sinus and the left main stem from the right coronary sinus. The origin and distribution of vessels in 6 patients who underwent CAG could not be accurately displayed. DSCT accurately showed the origin of coronary artery anomalies and the relationship between distribution and adjacent blood vessels. There were significant differences between the two methods (P<0.05). Conclusion DSCT can display the structure of coronary artery anomalies from multiple angles and directions, clarify the anatomical relationship between the opening, distribution and surrounding vessels and heart. It is safe and non-invasive. It can be used as a routine examination method for clinical screening of coronary artery anomalies.