Objective To evaluate the curative effect of chemoradiotherapy for lung cancer by dual-source CT perfusion imaging and its correlation with tumor angiogenesis. Methods A total of 64 patients with lung cancer treated with chemoradiotherapy in the hospital from July 2015 to September 2017 were selected as the subjects. The dual-source CT perfusion imaging scanning was performed before and after chemoradiotherapy. The blood flow (BF), blood volume (BV), perfusion parameters such as mean transit time (MTT) of contrast agent, time to peak (TTP) and permeability surface (PS) were compared between the effective group and the ineffective group before and after treatment. The diseased tissues of patients were collected after operation for pathological examination and immunohistochemical staining. The microvessel density (MVD) was measured and the expression of vascular endothelial growth factor (VEGF) was determined. The correlation between MVD and VEGF were statistically analyzed. Results Before treatment, the BF and BV values of the effective group were significantly higher than those of the ineffective group (P<0.05).After treatment, the values of effective group were significantly lower than those before treatment (P<0.05), but there was no significant difference of perfusion parameters in the ineffective groups before and after treatment (P>0.05). MDV was significantly positively correlated with BF and BV (P<0.05), and negatively correlated with TTP (P<0.05). VEGF was significantly positively correlated with BF, BV and PS (P<0.05), and negatively correlated with BV. Conclusion The parameters of dual-source CT perfusion imaging were conductive to predicting the curative effect of chemoradiotherapy for lung cancer, and they were of certain value in evaluating angiogenesis of lung cancer.