Objective To compare and analyze the diagnostic value of ultrasound contrast and enhanced CT in the diagnosis of pancreatic space-occupying lesions. Methods A total of 39 cases of patients with pancreatic lesions in our hospital were selected and were examined by ultrasound contrast and enhanced CT. Surgical pathology was taken as gold standard, and the diagnostic values of ultrasound contrast and enhanced CT were compared in the diagnosis of pancreatic lesions. Results All the 39 cases of patients with pancreatic lesions were single lesions, of which 32 cases were malignant and 7 cases were benign. The ultrasound contrast diagnosis of 27 malignant lesions and 5 benign lesions wewere consistent with the surgical pathology findings. The beginning enhancement time, beginning reduction time and transition time of ultrasound contrast in pancreatic malignant lesions were all significantly shorter than those in benign lesions and surrounding parenchyma (P<0.05), and the peak intensity was lower than that in benign lesions and surrounding parenchyma (P<0.05). There were 27 malignant lesions and 4 benign lesions among patients whose enhanced CT was consistent with the surgical pathology findings. There was no significant difference in the detection accuracy between ultrasound contrast and enhanced CT (82.05% vs 78.49%) (P>0.05). Conclusion Ultrasound contrast and enhanced CT have similar diagnostic detection rate and have high clinical diagnostic value in the treatment of pancreatic space-occupying lesions.