Objective To investigate the clinical value of minimally invasive puncture and drainage under CT in the treatment of cerebral hemorrhage. Methods 83 cases of cerebral hemorrhage in our hospital from January 2013 to January 2015 were selected as the subjects, and the clinical data of CT scanning and mini-invasive puncture and drainage were analyzed. Results 83 patients of cerebral hemorrhage undertook mini-invasive puncture and drainage under CT, 8 cases with the first hematoma clearance rate less than 20%, 19 cases with the rate of 20-50%, 56 cases with hematoma clearance rate more than 50%, 50.6% (42/83)patients with high hematoma removal rate. There were 9 cases with hematoma clearance time less than 3 days, 64 cases with hematoma clearance time from 3 to 8 days, 10 cases with hematoma clearance time over 8 days, and 87.9% (73/83) patients' hematoma were completely eliminated in 8 days. According to the CT images, 56 cases of skull drilling or small bone window were located accurately. Conclusion CT scan can effectively get the exact location of bleeding and calculate the volume of the intracerebral hemorrhage, which reduced the damage to the blood vessels in the brain and branches when using minimally invasive puncture drainage for treatment of cerebral hemorrhage, and reduced the possibility of vascular injury greatly. It provides accurate and reliable information for patients to undertake minimally invasive puncture drainage treatment and to choose of the puncture location, which is widely used in clinical application. It is a safe, reliable methods which has practical value.