Objective To explore thymoma CT imaging features and its relationship with pathology. Methods Arestrospective analysis of CT imaging and clinicopathological data was carried out in 64 patients with thymoma treated in our hospital from January 2014 to January 2016,thymoma CT features were observed, relationship between CT, pathological type and stage were analyzed. Results CT features: plain scan showed that thymoma lesions existed in mediastinum anterius part, irregular shapes accounted for 79.69%, uneven densities accounted for 68.75%, enhancement scanning showed obvious enhancement existed in 46 cases, pleural invasion existed in 25 cases, pulmonary nodule existed in 5 cases, mediastinal lymph node enlargement existed in 5 cases. There was a significant difference in tumor shape, edge, density, strengthening degree, local invasion and metastasis of benign (type A and type AB) and malignant (type B and type C) thymomas (P<0.05). There was no significant difference in thymoma CT staging and pathological staging (P>0.05), there were 24 cases of type A, type AB in CT stage I -II stage, 27 cases of type B, type C in III-IV stage. Conclusion There is a significant difference in pathological type A, type AB and type B, type C thymoma CT features,CT imaging features has great value in thymoma benign and malignant (pathological type) and clinical staging judgement, can provide an important basis for clinical diagnosis and prognosis evaluation of thymoma.