Objective To investigate the value of CT combined with enhanced scan in the stage diagnosis of liver failure. Methods Retrospectively analyze CT angiography data and clinical data of 47 patients from January 2014 to January 2016. Results Among 47 patients, there are 6 cases of acute liver failure, 12 cases of sub-acute liver failure, 14 cases of acute on chronic liver failure and 11 cases of chronic liver failure. There are 42 cases with large block fusion lesions on CT imaging during the early stage of liver failure, 16 cases with multiple nodular lesions on CT imaging during the middle stage of liver failure, and 7cases with small plaque lesions during the late stage of liver failure. Conclusion CT combined with enhanced scan is a safe, convenient and trusted preoperative examination method which can effectively reduce the potential harm caused by other inspection methods. Besides, it can effectively diagnose the type and stage of liver failure, according to pathological diagnosis, CT diagnosis accuracy rate of is up to 100%, which is worthy of further spread and application.