Objective To evaluate the value of three-dimensional reconstruction of multislice spiral CT scan in the localization of ocular foreign body. Methods 74 cases (74 eyes) suspicious patients with ocular foreign body were selected and accepted DR film and MSCT three-dimensional reconstruction respectively from August 2013 to December 2015, to compare the detection rate of two methods. The location of foreign body and the distances of foreign body with sagittal, horizontal and limbus were measured. Results 69 cases were confirmed with ocular foreign body by surgery in the total 74 cases, 28 cases were diagnosed by three-dimensional reconstruction of multislice spiral CT scan, withthe detection rate of 37.84%, while 21 cases were diagnosed by orbital digital radiography, with the detection rate of 28.38%. The difference was statistical significance(P=0.003), the location of foreign body and the distances of foreign body with sagittal, horizontal and limbus measured by three-dimensional reconstruction of multislice spiral CT scan were similar to those measured by orbital digital radiography. The differences had no statistical significance, the location of foreign body at (0.03±0.32) mm (t=1.296, P>1.296), the sagittal distances of foreign body were (0.03±0.41) mm (t=0.896, P> 0.896), the horizontal distances of foreign body were (0.05±0.35)mm (t=1.564, P>1.564), the distances between foreign body were (0.12±0.81) mm (t=1.182, P>1.182) to the limbus. Conclusion The detection rate of ocular foreign body by MSCT three-dimensional reconstruction was high and with high accuracy rate, which had important value for the localization of ocular foreign body.